Savella

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Savella or milnacipran (generic drug name) is an antidepressant that is also licensed for use to treat fibromyalgia in adults.[1][2] No studies have been carried out on the effectiveness of Savella in ME/CFS patients, although off-label use of psychiatric medications in ME/CFS has generally been ineffective.[3][4]

Theory[edit | edit source]

Evidence[edit | edit source]

Savella is an FDA-approved drug for adults with fibromyalgia,[5] with improvements in pain, sleep and more limited improvements in fatigue.

No clinical trials have been done for Savella/milnacipran in ME/CFS.

Clinicians[edit | edit source]

Risks and safety[edit | edit source]

Costs and availability[edit | edit source]

Perscription only drug.[2]

Notable studies[edit | edit source]

  • 2011, Comparative efficacy and acceptability of amitriptyline, duloxetine and milnacipran in fibromyalgia syndrome: a systematic review with meta-analysis[6] - (Full text)
  • 2014, Milnacipran versus other antidepressive agents for depression[7] - (Full text)
  • 2014, Effects of milnacipran on the multidimensional aspects of fatigue and the relationship of fatigue to pain and function: pooled analysis of 3 fibromyalgia trials[8] - (Full text)
  • 2015, Preliminary experience using milnacipran in patients with juvenile fibromyalgia: lessons from a clinical trial program[10] - (Full text)
  • 2016, The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled, Two-Way Crossover Study[11] - (Full text)
  • 2018, Milnacipran poorly modulates pain in patients suffering from fibromyalgia: a randomized double-blind controlled study[12] - (Full text)
  • 2018, Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia[13] - (Full text)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ "Savella". Drugs.com. Retrieved January 17, 2022.
  2. ↑ 2.0 2.1 "Milnacipran | Prescribing information". Drugs.com. Retrieved January 17, 2022.
  3. ↑ Qureshi, Aniqa G; Jha, Saurav K; Iskander, John; Avanthika, Chaithanya; Jhaveri, Sharan; Patel, Vithi Hitendra; Rasagna Potini, Bhuvana; Talha Azam, Ahmad. "Diagnostic Challenges and Management of Fibromyalgia". Cureus. 13 (10): e18692. doi:10.7759/cureus.18692. ISSN 2168-8184. PMC 8580749. PMID 34786265.
  4. ↑ Kim, Do-Young; Lee, Jin-Seok; Park, Samuel-Young; Kim, Soo-Jin; Son, Chang-Gue (January 6, 2020). "Systematic review of randomized controlled trials for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)". Journal of Translational Medicine. 18 (1): 1–12. doi:10.1186/s12967-019-02196-9. ISSN 1479-5876. PMC 6943902. PMID 31906979.
  5. ↑ "Savella Patient Information. Reference 4035361" (PDF). FDA. 2016.
  6. ↑ Häuser, Winfried; Petzke, Frank; Üçeyler, Nurcan; Sommer, Claudia (March 2011). "Comparative efficacy and acceptability of amitriptyline, duloxetine and milnacipran in fibromyalgia syndrome: a systematic review with meta-analysis". Rheumatology (Oxford, England). 50 (3): 532–543. doi:10.1093/rheumatology/keq354. ISSN 1462-0332. PMID 21078630.
  7. ↑ Nakagawa, Atsuo; Watanabe, Norio; Omori, Ichiro M; Barbui, Corrado; Cipriani, Andrea; McGuire, Hugh; Churchill, Rachel; Furukawa, Toshi A (July 8, 2009). "Milnacipran versus other antidepressive agents for depression". The Cochrane database of systematic reviews (3): CD006529. doi:10.1002/14651858.CD006529.pub2. ISSN 1469-493X. PMC 4164845. PMID 19588396.
  8. ↑ Mease, Philip J.; Palmer, Robert H.; Wang, Yong (August 2014). "Effects of Milnacipran on the Multidimensional Aspects of Fatigue and the Relationship of Fatigue to Pain and Function: Pooled Analysis of 3 Fibromyalgia Trials". JCR: Journal of Clinical Rheumatology. 20 (4): 195–202. doi:10.1097/RHU.0000000000000103. ISSN 1076-1608.
  9. ↑ Cording, Malene; Derry, Sheena; Phillips, Tudor; Moore, R Andrew; Wiffen, Philip J (October 20, 2015). "Milnacipran for pain in fibromyalgia in adults". The Cochrane Database of Systematic Reviews. 2015 (10): CD008244. doi:10.1002/14651858.CD008244.pub3. ISSN 1469-493X. PMC 6481368. PMID 26482422.
  10. ↑ Arnold, Lesley M.; Bateman, Lucinda; Palmer, Robert H.; Lin, Yuhua (June 26, 2015). "Preliminary experience using milnacipran in patients with juvenile fibromyalgia: lessons from a clinical trial program". Pediatric Rheumatology Online Journal. 13: 27. doi:10.1186/s12969-015-0025-9. ISSN 1546-0096. PMC 4480575. PMID 26112278.
  11. ↑ Ahmed, Mansoor; Aamir, Rozina; Jishi, Zahra; Scharf, Martin B. (January 15, 2016). "The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled, Two-Way Crossover Study". Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine. 12 (1): 79–86. doi:10.5664/jcsm.5400. ISSN 1550-9389. PMC 4702190. PMID 26414990.
  12. ↑ Pickering, Gisèle; Macian, Nicolas; Delage, Noémie; Picard, Pascale; Cardot, Jean-Michel; Sickout-Arondo, Sophia; Giron, Fatiha; Dualé, Christian; Pereira, Bruno; Marcaillou, Fabienne (August 10, 2018). "Milnacipran poorly modulates pain in patients suffering from fibromyalgia: a randomized double-blind controlled study". Drug Design, Development and Therapy. 12: 2485–2496. doi:10.2147/DDDT.S162810. ISSN 1177-8881. PMC 6089099. PMID 30127596.
  13. ↑ Welsch, Patrick; Üçeyler, Nurcan; Klose, Petra; Walitt, Brian; Häuser, Winfried (February 28, 2018). "Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia". The Cochrane Database of Systematic Reviews. 2018 (2): CD010292. doi:10.1002/14651858.CD010292.pub2. ISSN 1469-493X. PMC 5846183. PMID 29489029.
Retrieved from "https://me-pedia.org/w/index.php?title=Savella&oldid=239973"