Nudix hydrolase 15

Nudix Hydrolase 15 or NUDT15 or NUDT15D refers to either a gene or the enzyme encoded by it.

Function

NUDT15 expression affects the way that certain immunosuppressant drugs work.

Drug responses and genetic testing

Genetic testing for NUDT15 aims to improve clinical outcomes and reduce harm in people with inherited genetic mutations known to agfect drug responses.

There are a wide variety of different varoations, which may be broadly grouped into:

• Normal Metabolizer: Two copies of a normal function allele in the NUDT15 gene.
• Intermediate Metabolizer: One copy of a normal function allele and one copy of a no function allele in the NUDT15 gene.
• Poor Metabolizer: Two copies of no function alleles, low or absent activity of NUDT15. At high risk for toxicity with normal doses of thiopurine drugs.
• Possible Intermediate Metabolizer: One copy of a normal function allele and one copy of an uncertain function allele in the NUDT15 gene. At risk for myelosuppression with thiopurine drugs.
• Possible Poor Metabolizer: Two copies of uncertain function alleles or one copy of an uncertain function allele and one no function allele in the NUDT15 gene. At high risk for toxicity with thiopurine drugs.
• Indeterminate-Phasing Positive: Uncharacterized allele composition.

ME/CFS

Genetic studies of ME/CFS patients have not so far identified any TPMT genes as possibly associated with ME/CFS.

Thiopurine drugs have not been suggested as potentially useful for ME/CFS, and there is no guidance to avoid them.

Notable studies

• 2019, Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1 - (Full text)

See also

• Genetic testing
• Thiopurine S-Methyltransferase (TPMT)

Learn more

• NUDT15 Gene - Gene cards