Marked, rapid physical and/or cognitive fatigability in response to exertion

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Marked, rapid physical and/or cognitive fatigability in response to exertion, or rapid fatigability in response to exertion (which may be minimal such as activities of daily living or simple mental tasks) is a compulsory symptom of the International Consensus Criteria for myalgic encephalomyelitis.[1]. The fatigability is not simply sudden but is frequently debilitating, and cause a relapse.[1]

Prevalence[edit | edit source]

The marked, rapid and usually highly debilitating fatigability is one of the compulsory criteria of post-exertional neuroimmune exhaustion (PENE), the hallmark symptom of ME in the International Consensus Criteria. It is also mentioned in many other diagnostic criteria definitions of ME/CFS including the current CDC ME/CFS criteria.[2][1]

Symptom recognition[edit | edit source]

Notable studies[edit | edit source]

Possible causes[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ 1.01.11.2 Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, ACP; Speight, N; Vallings, R; Bateman, L; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Gerken, A; Jo, D; Lewis, DP; Light, AR; Light, KC; Marshall-Gradisnik, S; McLaren-Howard, J; Mena, I; Miwa, K; Murovska, M; Stevens, SR (2012), Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners (PDF), ISBN 978-0-9739335-3-6
  2. ↑ "Symptoms | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Centers for Disease Control and Prevention. January 27, 2021. Retrieved February 25, 2021.

post-exertional neuroimmune exhaustion (PENE) - An alternative term for post-exertional malaise (PEM), used by people who find that the word 'malaise' fails to capture the serious nature of the condition. Used in the Institute of Medicine (IOM) report.

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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.

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