Marked, rapid physical and/or cognitive fatigability in response to exertion

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Marked, rapid physical and/or cognitive fatigability in response to exertion, or rapid fatigability in response to exertion (which may be minimal such as activities of daily living or simple mental tasks) is a compulsory symptom of the International Consensus Criteria for myalgic encephalomyelitis.[1]. The fatigability is not simply sudden but is frequently debilitating, and cause a relapse.[1]

Prevalence[edit | edit source]

The marked, rapid and usually highly debilitating fatigability is one of the compulsory criteria of post-exertional neuroimmune exhaustion (PENE), the hallmark symptom of ME in the International Consensus Criteria. It is also mentioned in many other diagnostic criteria definitions of ME/CFS including the current CDC ME/CFS criteria.[2][1]

Symptom recognition[edit | edit source]

Notable studies[edit | edit source]

Possible causes[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

post-exertional neuroimmune exhaustion (PENE) - An alternative term for post-exertional malaise (PEM), used by people who find that the word 'malaise' fails to capture the serious nature of the condition. Used in the Institute of Medicine (IOM) report.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.