List of symptoms in ME CFS/ICC/PENE

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Post-exertional Neuroimmune Exhaustion

(PENE) is a compulsory neuroimmune symptom in the International Consensus Criteria diagnostic criteria for Myalgic Encephalomyelitis.

PENE is also known as Post-exertional Malaise (PEM).

This cardinal feature is a pathological inability to produce sufficient energy on demand with prominent symptoms primarily in the neuroimmune regions. Characteristics are:


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