Post-exertional symptom exacerbation

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Post-exertional symptom exacerbation or PESE is a significant increase in ME/CFS symptoms caused by over-exertion, which begins either immediately or may be delayed by hours or days.[1] PESE involves a mix of symptoms, for example exhaustion, acute flu-like symptoms, pain and worsening of other ME/CFS symptoms.[1]

Definitions[edit | edit source]

Post-exertional symptom exacerbation is defined in a number of different ways:

Prevalence[edit | edit source]

When listed as a separate diagnostic criteria, post-exertional symptom exacerbation is a mandatory symptom that is required for ME/CFS to be diagnosed.[1]

Symptom recognition[edit | edit source]

Notable studies[edit | edit source]

Possible causes[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

post-exertional neuroimmune exhaustion (PENE) - An alternative term for post-exertional malaise (PEM), used by people who find that the word 'malaise' fails to capture the serious nature of the condition. Used in the Institute of Medicine (IOM) report.

post-exertional malaise (PEM) - A notable exacerbation of symptoms brought on by small physical or cognitive exertions. PEM may be referred to as a "crash" or "collapse" and can last for days or weeks. Symptoms can include cognitive impairments, muscle pain, trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, and others.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.