Gabapentin is an anticonvulsant drug primarily developed to treat epilepsy, but now more commonly used for chronic pain. It is being used off-label for ME/CFS and fibromyalgia patients mostly to augment pain relief. Common brand names for gabapentin are Neurontin, Horizant, which is used for restless legs syndrome, and Gralise. Gabapentin is very similar to Lyrica (pregabalin).
Theory[edit | edit source]
Evidence[edit | edit source]
Gabapentin is one of the drugs suggested for use in people with ME/CFS to treat related pain; it is suggested in both the Canadian Consensus Criteria for ME/CFS and the International Consensus Criteria for ME.
Side Effects[edit | edit source]
More commonly ones reported are:
- unsteadiness, and continuous, uncontrolled, back-and-forth, or rolling eye movements
- weight gain
More commonly one reported in children are:
- aggressive behavior or other behavior problems
- concentration problems and change in school performance
- false sense of well-being
- hyperactivity or increase in body movements
- rapidly changing moods
- reacting too quickly, too emotional, or overreacting
- suspiciousness or distrust
Less commonly ones reported are:
- black, tarry stools
- chest pain
- depression, irritability, or other mood or mental changes
- loss of memory
- pain or swelling in the arms or legs
- painful or difficult urination
- shortness of breath
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- swollen glands
- unusual bleeding or bruising
- unusual tiredness or weakness
Learn more[edit | edit source]
- Gabapentin - drugs.com
- What's the difference between Lyrica and Gabapentin? - drugs.com
- Nov 9, 2016, Gabapentin Side Effects: The Dangers Of Off-Label Prescriptions’ Surprising Side Effects, by Samantha Olson
- 2016, Gabapentin (Neurontin) for ME
- June 07, 2004, When drugs are used off-label, by Daniel Costello
See also[edit | edit source]
References[edit | edit source]
- "Gabapentin - brand name list from Drugs.com". Drugs.com. Retrieved March 9, 2021.
- "Fibromyalgia treatment: Is Neurontin effective?". Mayo Clinic. Retrieved March 9, 2021.
- "Gabapentin Shown Effective for Fibromyalgia Pain". National Institutes of Health (NIH). September 29, 2015. Retrieved March 9, 2021.
- "Lyrica vs Gabapentin: What's the difference?". Drugs.com. Retrieved March 9, 2021.
- Carruthers, Bruce M.; Jain, Anil Kumar; De Meirleir, Kenny L.; Peterson, Daniel L.; Klimas, Nancy G.; Lerner, A. Martin; Bested, Alison C.; Flor-Henry, Pierre; Joshi, Pradip; Powles, AC Peter; Sherkey, Jeffrey A.; van de Sande, Marjorie I. (2003), "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols" (PDF), Journal of Chronic Fatigue Syndrome, 11 (2): 7–115, doi:10.1300/J092v11n01_02
- Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, ACP; Speight, N; Vallings, R; Bateman, L; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Gerken, A; Jo, D; Lewis, DP; Light, AR; Light, KC; Marshall-Gradisnik, S; McLaren-Howard, J; Mena, I; Miwa, K; Murovska, M; Stevens, SR (2012), Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners (PDF), ISBN 978-0-9739335-3-6
- "Gabapentin (Oral Route) Side Effects - Mayo Clinic". Mayo Clinic. Retrieved March 9, 2021.