From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Fluoxetine, also known by brand names Prozac and Sarafem among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used for depression, anxiety, panic, bulimia nervosa, obsessive-compulsive disorder (OCD) and premenstrual dysphoric disorder (PDD).[1]

It has shown potential antiviral activity against Coxsackie B4.[2]

Theory[edit | edit source]

Evidence[edit | edit source]

The Canadian Consensus criteria for ME/CFS states that fluoxetine may be useful for depression in people with ME/CFS.[3]

Risks and safety[edit | edit source]

Side effects include:

Costs and availability[edit | edit source]

Available on perscription only, in the form of a capsule or liquid. Widely available.[1]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 1.2 "Fluoxetine". drugs.com. Retrieved February 20, 2021.
  2. Alidjinou, Enagnon Kazali; Sané, Famara; Bertin, Antoine; Caloone, Delphine; Hober, Didier (April 2015), "Persistent infection of human pancreatic cells with Coxsackievirus B4 is cured by fluoxetine", Antiviral Research, 116: 51–54, doi:10.1016/j.antiviral.2015.01.010, ISSN 1872-9096, PMID 25655448
  3. 3.0 3.1 Carruthers, Bruce M.; Jain, Anil Kumar; De Meirleir, Kenny L.; Peterson, Daniel L.; Klimas, Nancy G.; Lerner, A. Martin; Bested, Alison C.; Flor-Henry, Pierre; Joshi, Pradip; Powles, AC Peter; Sherkey, Jeffrey A.; van de Sande, Marjorie I. (2003). "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols" (PDF). Journal of Chronic Fatigue Syndrome. 11 (2): 7–115. doi:10.1300/J092v11n01_02.