From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
paracetamol tablets
Acetaminophen or paracetamol. Photo by Michelle Tribe.

Acetaminophen, also known as paracetamol, panadol or tylenol, is a mild analgesic used to treat mild to moderate pain and fever. It is most commonly adminstered by mouth (in both soluble and tablet form) but can also be administered rectally or intravenously. Effects last between two and four hours.[1]

Use in chronic fatigue syndrome[edit | edit source]

Acetaminophen is commonly used alone and in combination with other painkillers to alleviate painful syptoms such as sore throat, headache, muscle pain, and joint pain, as well as low-grade fever relief.

Combinations[edit | edit source]

Acetaminophen is commonly paired with opiates such as codeine or tramadol, and/or with NSAIDs such as ibuprofen, naproxen or diclofenac. This can help relieve moderate to strong pain.

Evidence[edit | edit source]

The Canadian Consensus Criteria suggests using acetaminophen for ME/CFS as a "baseline analgesic", stating that it has a weak effect but few side effects.[2]

Dose[edit | edit source]

Suggested dose is 1-4 325mg tablets, every 4 hours as needed.[2]

Costs and availability[edit | edit source]

Acetaminophen is widely available at low cost. It can usually be purchased off the shelf without prescription.

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]