Carl-Gerhard Gottfries: Difference between revisions

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
VisualWikitext
m (Text replacement - "author-link8 = | last8" to "author-link7 = | last8")
 
(160 intermediate revisions by 2 users not shown)
Line 1: Line 1:
[[File:Carl-Gerhard Gottfries.png|200px|thumb|right|Source:Erik Nilsson]]
[[File:Carl-Gerhard Gottfries.png|200px|thumb|right|Source:Erik Nilsson]]
'''Carl-Gerhard Gottfries''', MD, PhD, is a Swedish professor, [[ME/CFS]] doctor, and founder of the [[Gottfries Clinic]], Mölndal, [[Sweden]]. After developing [[chronic fatigue syndrome]] following a case of the flu, he discovered that monthly injections of a staphylococcus aureus vaccine boosted his immune system, successfully allowing him to return to work. He has continued using a staphylococcus vaccine injection every month for over fifty years.<ref>{{Cite web|url=https://www.healthrising.org/blog/2015/11/21/gottfries-chronic-fatigue-syndrome-story/|title=Carl-Gerhard Gottfries: A Swedish Chronic Fatigue Syndrome Story|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref>  
'''Carl-Gerhard Gottfries''', MD, PhD, is a Swedish professor, [[ME/CFS]] doctor, and founder of the [[Gottfries Clinic]], Mölndal, [[Sweden]]. After developing [[chronic fatigue syndrome]] following a case of the flu, he discovered that monthly injections of a staphylococcus aureus vaccine boosted his immune system, successfully allowing him to return to work. He has continued using a staphylococcus vaccine injection every month for over fifty years.<ref>{{Cite web | url = https://www.healthrising.org/blog/2015/11/21/gottfries-chronic-fatigue-syndrome-story/ | title = Carl-Gerhard Gottfries: A Swedish Chronic Fatigue Syndrome Story | last = | first = | date = | website = | archive-url = | archive-date = |url-status = | access-date=}}</ref>  


==Clinic==
==Clinic==
Line 18: Line 18:
==Notable studies==
==Notable studies==


*1997, Increased concentrations of homocysteine in the cerebrospinal fluid in patients with [[fibromyalgia]] and [[chronic fatigue syndrome]]<ref>{{Cite journal|last=Regland|first=B|last2=Andersson|first2=M|last3=Abrahamsson|first3=L|last4=Bagby|first4=J|last5=Dyrehag|first5=LE|last6=Gottfries|first6=CG|author-link6=Carl-Gerhard Gottfries|date=1997|title=Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/9310111|journal=Scandinavian Journal of Rheumatology|volume=26|issue=4|pages=301-7|pmid=9310111|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pubmed/9310111 (Abstract)]
*1997, Increased concentrations of homocysteine in the cerebrospinal fluid in patients with [[fibromyalgia]] and [[chronic fatigue syndrome]]<ref>{{Cite journal | last = Regland | first = B | last2 = Andersson | first2 = M | last3 = Abrahamsson | first3 = L | last4 = Bagby | first4 = J | last5 = Dyrehag | first5 = LE | last6 = Gottfries | first6 = CG | author-link6 = Carl-Gerhard Gottfries | date = 1997 | title = Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome | url =https://www.ncbi.nlm.nih.gov/pubmed/9310111 | journal = Scandinavian Journal of Rheumatology | volume = 26 | issue = 4 | pages = 301-7|pmid=9310111|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pubmed/9310111 (Abstract)]
*1998, Effects of [[Staphylococcus vaccine|staphylococcus toxoid vaccine]] on pain and fatigue in patients with [[fibromyalgia]]/[[chronic fatigue syndrome]]<ref>{{Cite journal|last=Andersson|first=M|last2=Bagby|first2=JR|last3=Dyrehag|first3=L|last4=Gottfries|first4=C|author-link4=Carl-Gerhard Gottfries|date=1998|title=Effects of staphylococcus toxoid vaccine on pain and fatigue in patients with fibromyalgia/chronic fatigue syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/10700309|journal=European Journal of Pain|volume=2|issue=2|pages=133-142|pmid=10700309|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pubmed/10700309 (Abstract)]
*1998, Effects of [[Staphylococcus vaccine|staphylococcus toxoid vaccine]] on pain and fatigue in patients with [[fibromyalgia]]/[[chronic fatigue syndrome]]<ref>{{Cite journal | last = Andersson | first = M | last2 = Bagby | first2 = JR | last3 = Dyrehag | first3 = L | last4 = Gottfries | first4 = C | author-link4 = Carl-Gerhard Gottfries | date = 1998 | title = Effects of staphylococcus toxoid vaccine on pain and fatigue in patients with fibromyalgia/chronic fatigue syndrome | url =https://www.ncbi.nlm.nih.gov/pubmed/10700309 | journal = European Journal of Pain | volume = 2 | issue = 2 | pages = 133-142|pmid=10700309|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pubmed/10700309 (Abstract)]
*2000, Nickel [[Allergy]] is Found in a Majority of Women with [[Chronic Fatigue Syndrome]] and Muscle Pain - and may be Triggered by Cigarette Smoke and Dietary Nickel Intake <ref>{{Cite journal|last=Regland|first=Bjorn|last2=Zachrisson|first2=Olof|author-link2=Olof Zachrisson|last3=Stejskal|first3=Vera|last4=Gottfries|first4=Carl Gerhard|author-link4=Carl-Gerhard Gottfries|date=2000|title=Immunotherapy of Chronic Fatigue Syndrome: Therapeutic Interventions Aimed at Modulating the Th1/Th2 Cytokine Expression Balance|url=https://www.tandfonline.com/doi/abs/10.1300/J092v08n01_04|journal=Journal of Chronic Fatigue Syndrome|volume=8|issue=1|pages=57-65|doi=10.1300/J092v08n01_04|via=}}</ref>[https://www.tandfonline.com/doi/abs/10.1300/J092v08n01_04 (Abstract)]
*2000, Nickel [[Allergy]] is Found in a Majority of Women with [[Chronic Fatigue Syndrome]] and Muscle Pain - and may be Triggered by Cigarette Smoke and Dietary Nickel Intake <ref>{{Cite journal | last = Regland | first = Bjorn | last2 = Zachrisson | first2 = Olof | author-link2 = Olof Zachrisson | last3 = Stejskal | first3 = Vera | last4 = Gottfries | first4 = Carl Gerhard | author-link4 = Carl-Gerhard Gottfries | date = 2000 | title = Immunotherapy of Chronic Fatigue Syndrome: Therapeutic Interventions Aimed at Modulating the Th1/Th2 Cytokine Expression Balance | url =https://www.tandfonline.com/doi/abs/10.1300/J092v08n01_04 | journal = Journal of Chronic Fatigue Syndrome | volume = 8 | issue = 1 | pages = 57-65|doi=10.1300/J092v08n01_04|via=}}</ref>[https://www.tandfonline.com/doi/abs/10.1300/J092v08n01_04 (Abstract)]
*2002, A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale)<ref>{{Cite journal|last=Zachrisson|first=O|author-link=Olof Zachrisson|last2=Regland|first2=B|last3=Jahreskog|first3=M|last4=Kron|first4=M|last5=Gottfries|first5=CG|author-link5=Carl-Gerhard Gottfries|date=Jun 2002|title=A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale)|url=https://www.ncbi.nlm.nih.gov/pubmed/12069875|journal=J Psychosomatic Research|volume=52|issue=6|pages=501-9|pmid=12069875|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pubmed/12069875 (Abstract)]
*2002, A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale)<ref>{{Cite journal | last = Zachrisson | first = O | author-link = Olof Zachrisson | last2 = Regland | first2 = B | last3 = Jahreskog | first3 = M | last4 = Kron | first4 = M | last5 = Gottfries | first5 = CG | author-link5 = Carl-Gerhard Gottfries | date = Jun 2002 | title = A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale) | url = https://www.ncbi.nlm.nih.gov/pubmed/12069875 | journal = J Psychosomatic Research | volume = 52 | issue = 6 | pages = 501-9|pmid=12069875|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pubmed/12069875 (Abstract)]
*2004, Immune modulation with a staphylococcal preparation in fibromyalgia/chronic fatigue syndrome: relation between antibody levels and clinical improvement<ref>{{Cite journal|last=Zachrisson|first=O|author-link=Olof Zachrisson|last2=Colque-Navarro|first2=P|last3=Gottfries|first3=CG|author-link3=Carl-Gerhard Gottfries|last4=Regland|first4=B|last5=Möllby|first5=R|date=Feb 2004|title=Immune modulation with a staphylococcal preparation in fibromyalgia/chronic fatigue syndrome: relation between antibody levels and clinical improvement|url=https://www.ncbi.nlm.nih.gov/pubmed/14735403|journal=European Journal of Clinical Microbiology & Infectious Disease|volume=23|issue=2|pages=98-105|doi=10.1007/s10096-003-1062-8|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pubmed/14735403 (Abstract)]  
*2004, Immune modulation with a staphylococcal preparation in fibromyalgia/chronic fatigue syndrome: relation between antibody levels and clinical improvement<ref>{{Cite journal | last = Zachrisson | first = O | author-link = Olof Zachrisson | last2 = Colque-Navarro | first2 = P | last3 = Gottfries | first3 = CG | author-link3 = Carl-Gerhard Gottfries | last4 = Regland | first4 = B | last5 = Möllby | first5 = R | date = Feb 2004 | title = Immune modulation with a staphylococcal preparation in fibromyalgia/chronic fatigue syndrome: relation between antibody levels and clinical improvement | url = https://www.ncbi.nlm.nih.gov/pubmed/14735403 | journal = European Journal of Clinical Microbiology & Infectious Disease | volume = 23 | issue = 2 | pages = 98-105|doi=10.1007/s10096-003-1062-8|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pubmed/14735403 (Abstract)]  
*2006, Long-Term Treatment with a [[Staphylococcal vaccine|''Staphylococcus'' Toxoid Vaccine]] in Patients with [[Fibromyalgia]] and [[Chronic Fatigue Syndrome]]<ref>Carl-Gerhard Gottfries, Ove Häger, Björn Regland & [[Olof Zachrisson]]. (2006). Long-Term Treatment with a Staphylococcus Toxoid Vaccine in Patients with Fibromyalgia and Chronic Fatigue Syndrome. ''Journal of Chronic Fatigue Syndrome'', Vol. 13, Iss. 4, pp. 29-40. DOI:10.1300/J092v13n04_04</ref> [https://www.tandfonline.com/doi/abs/10.1300/J092v13n04_04 (Abstract)]
*2006, Long-Term Treatment with a [[Staphylococcal vaccine|''Staphylococcus'' Toxoid Vaccine]] in Patients with [[Fibromyalgia]] and [[Chronic Fatigue Syndrome]]<ref>Carl-Gerhard Gottfries, Ove Häger, Björn Regland & [[Olof Zachrisson]]. (2006). Long-Term Treatment with a Staphylococcus Toxoid Vaccine in Patients with Fibromyalgia and Chronic Fatigue Syndrome. ''Journal of Chronic Fatigue Syndrome'', Vol. 13, Iss. 4, pp. 29-40. DOI:10.1300/J092v13n04_04</ref> [https://www.tandfonline.com/doi/abs/10.1300/J092v13n04_04 (Abstract)]
*2011, Murine gammaretrovirus group G3 was not found in Swedish patients with [[ME/CFS|myalgic encephalomyelitis/chronic fatigue syndrome]] and [[fibromyalgia]]<ref name="Elfaitouri, 2011" /> [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024602 (Full Text)]
*2011, Murine gammaretrovirus group G3 was not found in Swedish patients with [[ME/CFS|myalgic encephalomyelitis/chronic fatigue syndrome]] and [[fibromyalgia]]<ref name="Elfaitouri, 2011" /> [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024602 (Full Text)]
Line 29: Line 29:
*2015, Response to [[Vitamin B12]] and [[Folic acid|Folic Acid]] in [[Myalgic Encephalomyelitis]] and [[Fibromyalgia]]<ref name="Regland, 2015" />[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406448/ (Full Text)]  
*2015, Response to [[Vitamin B12]] and [[Folic acid|Folic Acid]] in [[Myalgic Encephalomyelitis]] and [[Fibromyalgia]]<ref name="Regland, 2015" />[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406448/ (Full Text)]  
*2018, Infection Elicited [[Autoimmune disease|Autoimmunity]] and [[ME/CFS|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome]]: An Explanatory Model<ref name="Blomberg, 2018" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818468/ (Full Text)]
*2018, Infection Elicited [[Autoimmune disease|Autoimmunity]] and [[ME/CFS|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome]]: An Explanatory Model<ref name="Blomberg, 2018" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818468/ (Full Text)]
*2018, A randomised controlled trial of the monoaminergic stabiliser (-)-OSU6162 in treatment of myalgic encephalomyelitis/chronic fatigue syndrome<ref>{{Cite journal|last=Nilsson|first=MKL|last2=Zachrisson|first2=O|author-link2=Olof Zachrisson|last3=Gottfries|first3=C|author-link3=Carl-Gerhard Gottfries|last4=Matousek|first4=M|last5=Peilot|first5=B|last6=Forsmark|first6=S|last7=Schuit|first7=RC|last8=Carlsson|first8=ML|last9=Kloberg|first9=A||last10=Carlsson|first10=A|date=Jun 2018|title=A randomised controlled trial of the monoaminergic stabiliser (-)-OSU6162 in treatment of myalgic encephalomyelitis/chronic fatigue syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/29212562|journal=Acta Neuropsychiatrica|volume=30|issue=3|pages=148-157|doi=10.1017/neu.2017.35|pmid=29212562}}</ref> [https://www.ncbi.nlm.nih.gov/pubmed/29212562 (Abstract)]
*2018, A randomised controlled trial of the monoaminergic stabiliser (-)-OSU6162 in treatment of myalgic encephalomyelitis/chronic fatigue syndrome<ref>{{Cite journal | last = Nilsson | first = MKL | last2 = Zachrisson | first2 = O | author-link2 = Olof Zachrisson | last3 = Gottfries | first3 = C | author-link3 = Carl-Gerhard Gottfries | last4 = Matousek | first4 = M | last5 = Peilot | first5 = B | last6 = Forsmark | first6 = S | last7 = Schuit | first7 = RC | last8 = Carlsson | first8 = ML | last9 = Kloberg | first9 = A | last10 = Carlsson | first10 = A | date = Jun 2018 | title = A randomised controlled trial of the monoaminergic stabiliser (-)-OSU6162 in treatment of myalgic encephalomyelitis/chronic fatigue syndrome | url =https://www.ncbi.nlm.nih.gov/pubmed/29212562 | journal = Acta Neuropsychiatrica | volume = 30 | issue = 3 | pages = 148-157|doi=10.1017/neu.2017.35|pmid=29212562}}</ref> [https://www.ncbi.nlm.nih.gov/pubmed/29212562 (Abstract)]
*2019, Antibodies to Human [[Herpesviruses]] in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients<ref>{{Cite journal|last=Blomberg|first=Jonas|author-link=Jonas Blomberg|last2=Rizwan|first2=Muhammad|author-link2=|last3=Böhlin-Wiener|first3=Agnes|author-link3=|last4=Elfaitouri|first4=Amal|author-link4=|last5=Julin|first5=Per|author-link5=|last6=Zachrisson|first6=Olof|author-link6=Olof Zachrisson|last7=Rosén|first7=Anders|last8=Gottfries|first8=Carl-Gerhard|author-link8=Carl-Gerhard Gottfries|date=|title=Antibodies to Human Herpesviruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients|url=https://www.frontiersin.org/articles/10.3389/fimmu.2019.01946/abstract|journal=Frontiers in Immunology|volume=|issue=|pages=|doi=10.3389/fimmu.2019.01946|quote=|via=}}</ref> - [https://www.frontiersin.org/articles/10.3389/fimmu.2019.01946/full (Abstract)]
*2019, Antibodies to Human [[Herpesviruses]] in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients<ref>{{Cite journal | last = Blomberg | first = Jonas | author-link = Jonas Blomberg | last2 = Rizwan | first2 = Muhammad | author-link2 = | last3 = Böhlin-Wiener | first3 = Agnes | author-link3 = | last4 = Elfaitouri | first4 = Amal | author-link4 = | last5 = Julin | first5 = Per | author-link5 = | last6 = Zachrisson | first6 = Olof | author-link6 = Olof Zachrisson | last7 = Rosén | first7 = Anders | last8 = Gottfries | first8 = Carl-Gerhard | author-link8 = Carl-Gerhard Gottfries | date = | title = Antibodies to Human Herpesviruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients |url =https://www.frontiersin.org/articles/10.3389/fimmu.2019.01946/abstract | journal = Frontiers in Immunology | volume = | issue = | pages=|doi=10.3389/fimmu.2019.01946|quote=|via=}}</ref> - [https://www.frontiersin.org/articles/10.3389/fimmu.2019.01946/full (Abstract)]
 
*2020, Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients – A validation study in plasma and cerebrospinal fluid from two Swedish cohorts<ref name="Bynke2020">{{Cite journal | last = Bynke | first = Annie | author-link = | last2 = Julin | first2 = Per | author-link2 = | last3 = Gottfries | first3 = Carl-Gerhard | author-link3 = Carl-Gerhard Gottfries | last4 = Heidecke | first4 = Harald | author-link4 = | last5 = Scheibenbogen | first5 = Carmen | author-link5 = Carmen Scheibenbogen | last6 = Bergquist | first6 = Jonas | author-link6 = Jonas Bergquist | date = 2020-08-01 | title = Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients – A validation study in plasma and cerebrospinal fluid from two Swedish cohorts |url =http://www.sciencedirect.com/science/article/pii/S2666354620300727 | journal = Brain, Behavior, & Immunity - Health|language=en | volume = 7 | issue =  | pages = 100107|doi=10.1016/j.bbih.2020.100107|issn=2666-3546|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [http://www.sciencedirect.com/science/article/pii/S2666354620300727 (Full text)]


==See also==
==See also==
*[[Gottfries Clinic]]
*[[Staphylococcus aureus]]
*[[Staphylococcus aureus]]
*[[Staphylococcus vaccine]]
*[[Staphylococcus vaccine]]
*[[Sweden]]
*[[Sweden]]
*[[Dr Markov's chronic bacterial intoxication syndrome (CBIS) theory of ME/CFS]] (Dr Markov has evidence that ME/CFS is caused by a dysbiosis in the kidneys)


==Learn more==
==Learn more==
Line 45: Line 46:
==References==
==References==
<references>
<references>
<ref name="Blomberg, 2012">{{Citation
<ref name="Blomberg, 2012">{{Citation | last1 = Blomberg | first1 = Jonas | author-link1 = Jonas Blomberg | last2 =Blomberg | first2 = Fredrik | author-link2 = | last3 = Sjösten | first3 = Anna | author-link3 = | last4 = Sheikholvaezin | first4 = Ali | author-link4 = | last5 =Bölin-Wiener | first5 = Agnes | author-link5 = | last6 =Elfaitouri | first6 = Amal | author-link6 = | last7 = Hessel | first7 = Sanna | author-link7 = | last8 = Gottfries | first8 = Carl-Gerhard | author-link8 = Carl-Gerhard Gottfries | last9 =Zachrisson | first9 = Olof | author-link9 = Olof Zachrisson | last10 = Öhrmalma | first10 = Christina | author-link10 = | last11 = Jobs | first11 = Magnus | author-link11 = | last12 = Pipkorn | first12 = Rüdiger | author-link12 = | title = No Evidence for Xenotropic Murine Leukemia-Related Virus Infection in Sweden Using Internally Controlled Multiepitope Suspension Array Serology | journal = Clinical and Vaccine Immunology | volume = 19 | issue = 9 | page = 1399-1410 | date = 2012 | pmid = | doi = 10.1128/CVI.00391-12 }}</ref>
| last1   = Blomberg           | first1 = Jonas               | authorlink1 = Jonas Blomberg  
<ref name="Blomberg, 2018">{{Citation | last1 = Blomberg | first1 = Jonas | author-link1 = Jonas Blomberg | last2 = Gottfries | first2 = Carl-Gerhard | author-link2 = Carl-Gerhard Gottfries | last3 = Elfaitouri | first3 = Amal | author-link3 = | last4 = Rizwan | first4 = Muhammad | author-link4 = | last5 =Rosén | first5 = Anders| author-link5 = | title = Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model | journal = Frontiers in Immunology | volume = 2018 | issue = 9 | page = 229 | date = 2018 | pmid = | doi = 10.3389/fimmu.2018.00229 }}</ref>
| last2   = Blomberg           | first2 = Fredrik             | authorlink2 =  
<ref name="Elfaitouri, 2011">{{Citation | last1 = Elfaitouri | first1 = A | author-link1 = | last2 =Shao | first2 = X | author-link2 = | last3 = Mattsson Ulfstedt | first3 = J | author-link3 = | last4 = Muradrasoli | first4 = S | author-link4 = | last5 =Bölin Wiener | first5 = A | author-link5 = | last6 = Golbob | first6 = S | author-link6 = | last7 = Ohrmalm | first7 = C | author-link7 = | last8 = Matousek | first8 = M | author-link8 = | last9 =Zachrisson | first9 = O | author-link9 = Olof Zachrisson | last10 = Gottfries | first10 = C-G | author-link10 = Carl-Gerhard Gottfries | last11 = Blomberg | first11 = J | author-link11 = Jonas Blomberg | title = Murine gammaretrovirus group G3 was not found in Swedish patients with myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia. | journal = PLoS One | volume =6 | issue = 10 | page = | date = 2011 | pmid = | doi = 10.1371/journal.pone.0024602 }}</ref>
| last3   = Sjösten           | first3 = Anna                 | authorlink3 =  
<ref name="Elfaitouri, 2013">{{Citation | last1 = Elfaitouri | first1 = A | author-link1 = | last2 =Herrmann | first2 = B | author-link2 = | last3 = Bölin-Wiener | first3 = A | author-link3 = | last4 = Wang | first4 = Y | author-link4 = | last5 = Gottfries | first5 = C-G | author-link5 = Carl-Gerhard Gottfries | last6 =Zachrisson | first6 = O | author-link6 = Olof Zachrisson | last7 = Pipkorn | first7 = R | author-link7 = | last8 = Rönnblom | first8 = L | author-link8 = | last9 =Blomberg | first9 = J | author-link9 = Jonas Blomberg  | title = Epitopes of Microbial and Human Heat Shock Protein 60 and Their Recognition in Myalgic Encephalomyelitis | journal = PLoS One | volume = 8 | issue = 11 | page = | date = 2013 | pmid = | doi = 10.1371/journal.pone.0081155 }}</ref>
| last4   = Sheikholvaezin     | first4 = Ali                 | authorlink4 =  
<ref name="Regland, 2015">{{Citation | last1 = Regland | first1 = Björn | author-link1 = | last2 =Forsmark | first2 = Sara | author-link2 = | last3 = Halaouate | first3 = Lena | author-link3 = | last4 = Matousek | first4 = Michael | author-link4 = | last5 = Peilot | first5 = Birgitta | author-link5 = | last6 =Zachrisson | first6 = Olof | author-link6 = Olof Zachrisson | last7 = Gottfries | first7 = Carl-Gerhard | author-link8 = Carl-Gerhard Gottfries | title = Response to Vitamin B12 and Folic Acid in Myalgic Encephalomyelitis and Fibromyalgia. | journal = PLoS ONE | volume = 10 | issue = 4 | page = | date = 2015 | pmid = | doi = 10.1371/journal.pone.0124648 }}</ref>
| last5   = Bölin-Wiener       | first5 = Agnes               | authorlink5 =  
| last6   = Elfaitouri         | first6 = Amal                 | authorlink6 =  
| last7   = Hessel             | first7 = Sanna               | authorlink7 =  
| last8   = Gottfries         | first8 = Carl-Gerhard         | authorlink8 = Carl-Gerhard Gottfries
| last9   = Zachrisson         | first9 = Olof                 | authorlink9 = Olof Zachrisson
| last10 = Öhrmalma           | first10 = Christina           | authorlink10 =  
| last11 = Jobs               | first11 = Magnus             | authorlink11 =
| last12 = Pipkorn           | first12 = Rüdiger             | authorlink12 =
| title   = No Evidence for Xenotropic Murine Leukemia-Related Virus Infection in Sweden Using Internally Controlled Multiepitope Suspension Array Serology  
| journal = Clinical and Vaccine Immunology   | volume = 19   | issue = 9   | page = 1399-1410  
| date   = 2012
| pmid   =  
| doi     = 10.1128/CVI.00391-12  
}}
</ref>
<ref name="Blomberg, 2018">{{Citation
| last1   = Blomberg           | first1 = Jonas               | authorlink1 = Jonas Blomberg  
| last2   = Gottfries         | first2 = Carl-Gerhard         | authorlink2 = Carl-Gerhard Gottfries
| last3   = Elfaitouri         | first3 = Amal                 | authorlink3 =  
| last4   = Rizwan             | first4 = Muhammad             | authorlink4 =  
| last5   = Rosén             | first5 = Anders               | authorlink5 =  
| title   = Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model  
| journal = Frontiers in Immunology   | volume = 2018   | issue = 9   | page = 229  
| date   = 2018
| pmid   =  
| doi     = 10.3389/fimmu.2018.00229  
}}
</ref>
<ref name="Elfaitouri, 2011">{{Citation
| last1   = Elfaitouri         | first1 = A       | authorlink1 =  
| last2   = Shao               | first2 = X       | authorlink2 =  
| last3   = Mattsson Ulfstedt | first3 = J       | authorlink3 =  
| last4   = Muradrasoli       | first4 = S       | authorlink4 =  
| last5   = Bölin Wiener       | first5 = A       | authorlink5 =  
| last6   = Golbob             | first6 = S       | authorlink6 =  
| last7   = Ohrmalm           | first7 = C       | authorlink7 =  
| last8   = Matousek           | first8 = M       | authorlink8 =  
| last9   = Zachrisson         | first9 = O       | authorlink9 = Olof Zachrisson
| last10 = Gottfries         | first10 = C-G   | authorlink10 = Carl-Gerhard Gottfries
| last11 = Blomberg           | first11 = J     | authorlink11 = Jonas Blomberg  
| title   = Murine gammaretrovirus group G3 was not found in Swedish patients with myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia.
| journal = PLoS One   | volume =6   | issue = 10   | page =  
| date   = 2011
| pmid   =  
| doi     = 10.1371/journal.pone.0024602
}}
</ref>
<ref name="Elfaitouri, 2013">{{Citation
| last1   = Elfaitouri     | first1 = A               | authorlink1 =
| last2   = Herrmann       | first2 = B               | authorlink2 =  
| last3   = Bölin-Wiener   | first3 = A               | authorlink3 =  
| last4   = Wang           | first4 = Y               | authorlink4 =  
| last5   = Gottfries       | first5 = C-G             | authorlink5 = Carl-Gerhard Gottfries
| last6   = Zachrisson     | first6 = O               | authorlink6 = Olof Zachrisson
| last7   = Pipkorn         | first7 = R               | authorlink7 =  
| last8   = Rönnblom       | first8 = L               | authorlink8 =  
| last9   = Blomberg       | first9 = J               | authorlink9 = Jonas Blomberg   
| title   = Epitopes of Microbial and Human Heat Shock Protein 60 and Their Recognition in Myalgic Encephalomyelitis
| journal = PLoS One   | volume = 8   | issue = 11   | page =  
| date   = 2013
| pmid   =  
| doi     = 10.1371/journal.pone.0081155
}}
</ref>
<ref name="Regland, 2015">{{Citation
| last1   = Regland           | first1 = Björn               | authorlink1 =  
| last2   = Forsmark           | first2 = Sara                 | authorlink2 =  
| last3   = Halaouate         | first3 = Lena                 | authorlink3 =  
| last4   = Matousek           | first4 = Michael             | authorlink4 =  
| last5   = Peilot             | first5 = Birgitta             | authorlink5 =  
| last6   = Zachrisson         | first6 = Olof                 | authorlink6 = Olof Zachrisson
| last7   = Gottfries         | first7 = Carl-Gerhard         | authorlink7 = Carl-Gerhard Gottfries
| title   = Response to Vitamin B12 and Folic Acid in Myalgic Encephalomyelitis and Fibromyalgia.
| journal = PLoS ONE   | volume = 10 | issue = 4   | page =  
| date   = 2015
| pmid   =  
| doi     = 10.1371/journal.pone.0124648
}}
</ref>
</references>
</references>
[[Category:Clinicians]]
[[Category:Clinicians]]

Latest revision as of 19:56, July 29, 2023

Source:Erik Nilsson

Carl-Gerhard Gottfries, MD, PhD, is a Swedish professor, ME/CFS doctor, and founder of the Gottfries Clinic, Mölndal, Sweden. After developing chronic fatigue syndrome following a case of the flu, he discovered that monthly injections of a staphylococcus aureus vaccine boosted his immune system, successfully allowing him to return to work. He has continued using a staphylococcus vaccine injection every month for over fifty years.[1]

Clinic[edit | edit source]

Gottfries Clinic AB (Gottfriesmottagningen), was previously financed through the health-care system, but now is privately operated. It is a specialty clinic for the 1) evaluation, diagnosis and treatment of patients with fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), chronic fatigue and widespread muscular pain, and 2) research for developing and treatment for such patients. Located at Krokslätts Torg 5, Mölndal, Sweden.[2]

2017 Ramsay Award[edit | edit source]

A team comprised of Dr. Jonas Bergquist and Dr. Jonas Blomberg of Uppsala University and Dr. Carl-Gerhard Gottfries and Dr. Olof Zachrisson of the Gottfries Clinic were awarded a 2017 Ramsay Award grant from the Solve ME/CFS Initiative for research into biomarkers for initiation (infection) and metabolic derangement in ME/CFS.[3]

Talks and interviews[edit | edit source]

Notable studies[edit | edit source]

  • 2020, Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients – A validation study in plasma and cerebrospinal fluid from two Swedish cohorts[17] - (Full text)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ "Carl-Gerhard Gottfries: A Swedish Chronic Fatigue Syndrome Story".
  2. ↑ http://www.gottfriesclinic.se/in-english/gottfries-clinic/
  3. ↑ http://solvecfs.org/2017-ramsay-award-program-results/
  4. ↑ Regland, B; Andersson, M; Abrahamsson, L; Bagby, J; Dyrehag, LE; Gottfries, CG (1997). "Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome". Scandinavian Journal of Rheumatology. 26 (4): 301–7. PMID 9310111.
  5. ↑ Andersson, M; Bagby, JR; Dyrehag, L; Gottfries, C (1998). "Effects of staphylococcus toxoid vaccine on pain and fatigue in patients with fibromyalgia/chronic fatigue syndrome". European Journal of Pain. 2 (2): 133–142. PMID 10700309.
  6. ↑ Regland, Bjorn; Zachrisson, Olof; Stejskal, Vera; Gottfries, Carl Gerhard (2000). "Immunotherapy of Chronic Fatigue Syndrome: Therapeutic Interventions Aimed at Modulating the Th1/Th2 Cytokine Expression Balance". Journal of Chronic Fatigue Syndrome. 8 (1): 57–65. doi:10.1300/J092v08n01_04.
  7. ↑ Zachrisson, O; Regland, B; Jahreskog, M; Kron, M; Gottfries, CG (June 2002). "A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale)". J Psychosomatic Research. 52 (6): 501–9. PMID 12069875.
  8. ↑ Zachrisson, O; Colque-Navarro, P; Gottfries, CG; Regland, B; Möllby, R (February 2004). "Immune modulation with a staphylococcal preparation in fibromyalgia/chronic fatigue syndrome: relation between antibody levels and clinical improvement". European Journal of Clinical Microbiology & Infectious Disease. 23 (2): 98–105. doi:10.1007/s10096-003-1062-8.
  9. ↑ Carl-Gerhard Gottfries, Ove Häger, Björn Regland & Olof Zachrisson. (2006). Long-Term Treatment with a Staphylococcus Toxoid Vaccine in Patients with Fibromyalgia and Chronic Fatigue Syndrome. Journal of Chronic Fatigue Syndrome, Vol. 13, Iss. 4, pp. 29-40. DOI:10.1300/J092v13n04_04
  10. ↑ Elfaitouri, A; Shao, X; Mattsson Ulfstedt, J; Muradrasoli, S; Bölin Wiener, A; Golbob, S; Ohrmalm, C; Matousek, M; Zachrisson, O; Gottfries, C-G; Blomberg, J (2011), "Murine gammaretrovirus group G3 was not found in Swedish patients with myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia.", PLoS One, 6 (10), doi:10.1371/journal.pone.0024602
  11. ↑ Blomberg, Jonas; Blomberg, Fredrik; Sjösten, Anna; Sheikholvaezin, Ali; Bölin-Wiener, Agnes; Elfaitouri, Amal; Hessel, Sanna; Gottfries, Carl-Gerhard; Zachrisson, Olof; Öhrmalma, Christina; Jobs, Magnus; Pipkorn, Rüdiger (2012), "No Evidence for Xenotropic Murine Leukemia-Related Virus Infection in Sweden Using Internally Controlled Multiepitope Suspension Array Serology", Clinical and Vaccine Immunology, 19 (9): 1399-1410, doi:10.1128/CVI.00391-12
  12. ↑ Elfaitouri, A; Herrmann, B; Bölin-Wiener, A; Wang, Y; Gottfries, C-G; Zachrisson, O; Pipkorn, R; Rönnblom, L; Blomberg, J (2013), "Epitopes of Microbial and Human Heat Shock Protein 60 and Their Recognition in Myalgic Encephalomyelitis", PLoS One, 8 (11), doi:10.1371/journal.pone.0081155
  13. ↑ Regland, Björn; Forsmark, Sara; Halaouate, Lena; Matousek, Michael; Peilot, Birgitta; Zachrisson, Olof; Gottfries, Carl-Gerhard (2015), "Response to Vitamin B12 and Folic Acid in Myalgic Encephalomyelitis and Fibromyalgia.", PLoS ONE, 10 (4), doi:10.1371/journal.pone.0124648
  14. ↑ Blomberg, Jonas; Gottfries, Carl-Gerhard; Elfaitouri, Amal; Rizwan, Muhammad; Rosén, Anders (2018), "Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model", Frontiers in Immunology, 2018 (9): 229, doi:10.3389/fimmu.2018.00229
  15. ↑ Nilsson, MKL; Zachrisson, O; Gottfries, C; Matousek, M; Peilot, B; Forsmark, S; Schuit, RC; Carlsson, ML; Kloberg, A; Carlsson, A (June 2018). "A randomised controlled trial of the monoaminergic stabiliser (-)-OSU6162 in treatment of myalgic encephalomyelitis/chronic fatigue syndrome". Acta Neuropsychiatrica. 30 (3): 148–157. doi:10.1017/neu.2017.35. PMID 29212562.
  16. ↑ Blomberg, Jonas; Rizwan, Muhammad; Böhlin-Wiener, Agnes; Elfaitouri, Amal; Julin, Per; Zachrisson, Olof; Rosén, Anders; Gottfries, Carl-Gerhard. "Antibodies to Human Herpesviruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients". Frontiers in Immunology. doi:10.3389/fimmu.2019.01946.
  17. ↑ Bynke, Annie; Julin, Per; Gottfries, Carl-Gerhard; Heidecke, Harald; Scheibenbogen, Carmen; Bergquist, Jonas (August 1, 2020). "Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients – A validation study in plasma and cerebrospinal fluid from two Swedish cohorts". Brain, Behavior, & Immunity - Health. 7: 100107. doi:10.1016/j.bbih.2020.100107. ISSN 2666-3546.

antibodies Antibody/immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.

randomized controlled trial (RCT) - A trial in which participants are randomly assigned to two groups, with one group receiving the treatment being studied and a control or comparison group receiving a sham treatment, placebo, or comparison treatment.

antibodies Antibody/immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

autoantibody An antibody that works against the body's own antigens, a hallmark of autoimmune diseases. Autoantibodies are the opposite of an antibodies.

β β / Β. Greek letter beta (a symbol used in science), equivalent to "b".

cholinergic Involving the neurotransmitter acetylcholine. Cholinergic side effects include diarrhea, blurred vision, decreased intraocular pressure, contricted pupil in the eyes, sweating, increased saliva and mucus on the lungs, bronchial constriction, increased gastrointestinal tone, decreased blood pressure, slow heart rate, and contraction of bladder detrusor muscle. muscle spasms/cramps, low blood pressure, slowed heart rate, nausea and vomiting, increased saliva and sweating, shortness of breath, and urinating more often.

somatic symptom disorder A psychiatric term to describe an alleged condition whereby a person's thoughts somehow cause physical symptoms. The actual existence of such a condition is highly controversial, due to a lack of scientific evidence. It is related to other psychiatric terms, such as "psychosomatic", "neurasthenia", and "hysteria". Older terms include "somatization", "somatoform disorder", and "conversion disorder". Such terms refer to a scientifically-unsupported theory that claims that a wide range of physical symptoms can be created by the human mind, a theory which has been criticized as "mind over matter" parapsychology, a pseudoscience.

Retrieved from "https://me-pedia.org/w/index.php?title=Carl-Gerhard_Gottfries&oldid=241599"