Serotonin hypothesis

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

The central fatigue or serotonin hypothesis of ME/CFS states that excessive levels of the neurotransmitter serotonin are involved in the pathophysiology of ME/CFS, and are directly responsible for symptoms such as fatigue.[1]

Theory[edit | edit source]

In 2024, Lee and colleagues published research stating that they had developed an animal model of ME/CFS involving serotonin hyperactivity and CFS-like symptoms, but this has not yet been replicated.[2]

Evidence[edit | edit source]

Treatment[edit | edit source]

Notable studies[edit | edit source]

  • 2024, Central 5-HTergic hyperactivity induces myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-like pathophysiology[2] - (Full text)
  • 2006, Central fatigue: the serotonin hypothesis and beyond[1] - (Full text)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 Meeusen, Romain; Watson, Philip; Hasegawa, Hiroshi; Roelands, Bart; Piacentini, Maria F. (October 1, 2006). "Central Fatigue". Sports Medicine. 36 (10): 881–909. doi:10.2165/00007256-200636100-00006. ISSN 1179-2035.
  2. 2.0 2.1 Lee, Jin-Seok; Kang, Ji-Yun; Park, Samuel-Young; Hwang, Seung-Ju; Bae, Sung-Jin; Son, Chang-Gue (January 8, 2024). "Central 5-HTergic hyperactivity induces myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-like pathophysiology". Journal of Translational Medicine. 22 (1): 34. doi:10.1186/s12967-023-04808-x. ISSN 1479-5876. PMC 10773012. PMID 38191373.