[Close]
- This page was created by volunteers like you!
- Help us make it even better. To learn more about contributing to MEpedia, click here.
- Join the movement
- Visit #MEAction to find support or take action. Donate today to help us improve and expand this project.
- Congratulations!
- MEpedia has got over 30 million views as of August 2022!
Serotonin hypothesis
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
 | This article is a stub. |
The central fatigue or serotonin hypothesis of ME/CFS states that excessive levels of the neurotransmitter serotonin are involved in the pathophysiology of ME/CFS, and are directly responsible for symptoms such as fatigue.[1]
Theory[edit | edit source]
In 2024, Lee and colleagues published research stating that they had developed an animal model of ME/CFS involving serotonin hyperactivity and CFS-like symptoms, but this has not yet been replicated.[2]
Evidence[edit | edit source]
Treatment[edit | edit source]
Notable studies[edit | edit source]
- 2024, Central 5-HTergic hyperactivity induces myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-like pathophysiology[2] - (Full text)
- 2006, Central fatigue: the serotonin hypothesis and beyond[1] - (Full text)
See also[edit | edit source]
Learn more[edit | edit source]
References[edit | edit source]
- ↑ Jump up to: 1.0 1.1 Meeusen, Romain; Watson, Philip; Hasegawa, Hiroshi; Roelands, Bart; Piacentini, Maria F. (October 1, 2006). "Central Fatigue". Sports Medicine. 36 (10): 881–909. doi:10.2165/00007256-200636100-00006. ISSN 1179-2035.
- ↑ Jump up to: 2.0 2.1 Lee, Jin-Seok; Kang, Ji-Yun; Park, Samuel-Young; Hwang, Seung-Ju; Bae, Sung-Jin; Son, Chang-Gue (January 8, 2024). "Central 5-HTergic hyperactivity induces myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-like pathophysiology". Journal of Translational Medicine. 22 (1): 34. doi:10.1186/s12967-023-04808-x. ISSN 1479-5876. PMC 10773012. PMID 38191373.
