Peripheral blood mononuclear cell

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Peripheral Blood Mononuclear Cells or PBMCs are types of white blood cells with a round nuclei, including lymphocytes, macrophages and monocytes, but not granulocytes (polymorphonuclear leucocytes like neutophils, eosinophils and basophils).[1][2]

PBMCs are less dense than granulocytes, and less dense than red blood cells.[3]

See also[edit | edit source]

Notable studies[edit | edit source]

  • 2001, G-Actin Cleavage Parallels 2-5A-Dependent RNase L Cleavage in Peripheral Blood Mononuclear Cells—Relevance to a Possible Serum-Based Screening Test for Dysregulations in the 2-5A Pathway[4](Abstract)
  • 2017, Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients[5](Full Text)
  • 2018, A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy[6](Abstract)
  • 2018, A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)[7](Full text)

Learn more[edit | edit source]

References[edit | edit source]

  1. Oellerich, Michael; Dasgupta, Amitava (2015). "Chapter 9 - Intracellular concentrations of immunosuppressants". Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring. Elsevier. p. 200. ISBN 9780128011331. 
  2. Brooker, Chris (2008). Churchill Livingstone Medical Dictionary E-Book. Elsevier Health Sciences. pp. 206, 369. ISBN 9780080982458. 
  3. Bittersohl, Heike; Steimer, Werner (2016). "Intracellular concentrations of immunosuppressants". Elsevier: 199–226. doi:10.1016/b978-0-12-800885-0.00009-6. ISBN 9780128008850. 
  4. Roelens, Simon; Herst, C. Vincent; D'Haese, Anne; De Smet, Karen; Frémont, Marc; De Meirleir, Kenny; Englebienne, Patrick (Jan 1, 2001). "G-Actin Cleavage Parallels 2-5A-Dependent RNase L Cleavage in Peripheral Blood Mononuclear Cells—Relevance to a Possible Serum-Based Screening Test for Dysregulations in the 2-5A Pathway". Journal of Chronic Fatigue Syndrome. 8 (3-4): 63–82. doi:10.1300/J092v08n03_07. ISSN 1057-3321. 
  5. Nguyen, T.; Johnston, S.; Chacko, A.; Gibson, D.; Cepon, J.; Smith, D.; Staines, D.; Marshall-Gradisnik, S. (2017), "Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients", Asian Pac J Allergy Immunol, 35 (2): 75-81, doi:10.12932/AP0771 
  6. Xu, Jiabao; Potter, Michelle; Tomas, Cara; Elson, Jo; Morten, Karl; Poulton, Joanna; Wang, Ning; Jin, Hanqing; Hou, Zhaoxu (2018). "A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy". The Analyst. doi:10.1039/C8AN01437J. ISSN 0003-2654. 
  7. Davis, R. W.; Wilhelmy, J.; Nemat-Gorgani, M.; Kashi, A.; Esfandyarpour, R. (Apr 25, 2019). "A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)". Proceedings of the National Academy of Sciences: 201901274. doi:10.1073/pnas.1901274116. ISSN 0027-8424. PMID 31036648. 

Myalgic encephalomyelitis or M.E. has different diagnostic criteria to chronic fatigue syndrome; neurological symptoms are required but fatigue is an optional symptom.<ref name="ICP2011primer">{{Citation

Myalgic encephalomyelitis or chronic fatigue syndrome, often used when both illnesses are considered the same.

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