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Nortriptyline

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
(Redirected from Pamelor)

Nortriptyline is a tricyclic antidepressant.[1] It is also marketed under the brand names Aventyl and Pamelor.[1]

Theory[edit | edit source]

Potential uses[edit | edit source]

Nortriptyline is licensed for use for clinical depression, and may be used off-label for anxiety, insomnia or sleep problems, nerve pain or chronic pain.[2][3]

Evidence[edit | edit source]

A Cochrane review in 2015 found insufficient evidence to recommend nortriptyline for nerve pain in adults.[4]

The medical practitioners' primer for the International Consensus Criteria of myalgic encephalomyelitis suggests nortriptyline may be useful for pain in patients with ME/CFS, but suggests other drugs for sleep problems and secondary depression. There is more evidence for the use of nortriptyline in fibromyalgia.[5]

Risks and safety[edit | edit source]

Side effects can be severe.[5]

Costs and availability[edit | edit source]

Nortriptyline is an inexpensive prescription-only medicine.

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. ↑ Jump up to: 1.0 1.1 "Nortriptyline: MedlinePlus Drug Information". medlineplus.gov. Retrieved January 8, 2019.
  2. ↑ "Nortriptyline: Uses, Dosage & Side Effects". Drugs.com. Retrieved February 12, 2021.
  3. ↑ "Complex regional pain syndrome - Treatment". National Health Service. October 19, 2017. Retrieved February 12, 2021.
  4. ↑ "Nortriptyline for neuropathic pain in adults". Cochrane. 2015. Retrieved February 12, 2021.
  5. ↑ Jump up to: 5.0 5.1 Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, ACP; Speight, N; Vallings, R; Bateman, L; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Gerken, A; Jo, D; Lewis, DP; Light, AR; Light, KC; Marshall-Gradisnik, S; McLaren-Howard, J; Mena, I; Miwa, K; Murovska, M; Stevens, SR (2012), Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners (PDF), ISBN 978-0-9739335-3-6

adverse reaction Any unintended or unwanted response to a treatment, whether in a clinical trial or licensed treatment. May be minor or serious.

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