Nortriptyline
Nortriptyline is a tricyclic antidepressant.[1] It is also marketed under the brand names Aventyl and Pamelor.[1]
Theory
Potential uses
Nortriptyline is licensed for use for clinical depression, and may be used off-label for anxiety, insomnia or sleep problems, nerve pain or chronic pain.[2][3]
Evidence
A Cochrane review in 2015 found insufficient evidence to recommend nortriptyline for nerve pain in adults.[4]
The medical practitioners' primer for the International Consensus Criteria of myalgic encephalomyelitis suggests nortriptyline may be useful for pain in patients with ME/CFS, but suggests other drugs for sleep problems and secondary depression. There is more evidence for the use of nortriptyline in fibromyalgia.[5]
Risks and safety
Side effects can be severe.[5]
Costs and availability
Nortriptyline is an inexpensive prescription-only medicine.
Learn more
See also
References
- ↑ 1.0 1.1 "Nortriptyline: MedlinePlus Drug Information". medlineplus.gov. Retrieved January 8, 2019.
- ↑ "Nortriptyline: Uses, Dosage & Side Effects". Drugs.com. Retrieved February 12, 2021.
- ↑ "Complex regional pain syndrome - Treatment". National Health Service. October 19, 2017. Retrieved February 12, 2021.
- ↑ "Nortriptyline for neuropathic pain in adults". Cochrane. 2015. Retrieved February 12, 2021.
- ↑ 5.0 5.1 Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, ACP; Speight, N; Vallings, R; Bateman, L; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Gerken, A; Jo, D; Lewis, DP; Light, AR; Light, KC; Marshall-Gradisnik, S; McLaren-Howard, J; Mena, I; Miwa, K; Murovska, M; Stevens, SR (2012), Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners (PDF), ISBN 978-0-9739335-3-6
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