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Monoamine oxidase inhibitor
Monoamine oxidase inhibitors, also called MAOIs or MAO inhibitors, are a fairly old class antidepressants.[1] They were the first antidepressants to be developed.[1] Though effective, they have been replaced as a first-line treatment following the development of other antidepressants posing fewer safety and side effect issues.[1]
Theory[edit | edit source]
Evidence[edit | edit source]
No antidepressants have been found to cause significant improvement in ME/CFS, although some may be useful for co-existing depression, or for treating pain and/or sleep problems.[2][3]
Clinicians[edit | edit source]
Risks and safety[edit | edit source]
Use of MAOIs typically involves dietary restrictions owing to dangerous side effects that can result from interactions with some foods.[1] Nevertheless, MAOIs can still be a good treatment option for depression, especially in cases where other antidepressants have been ineffective.[1]
As of June 2016, the FDA has approved the following MAOIs to treat depression:
- Isocarboxazid (Marplan)
- Phenelzine (Nardil)
- Selegiline (Emsam)
- Tranylcypromine (Parnate)
See also[edit | edit source]
Learn more[edit | edit source]
References[edit | edit source]
- ↑ Jump up to: 1.0 1.1 1.2 1.3 1.4 "Monoamine oxidase inhibitors (MAOIs)". Mayo Clinic. Retrieved January 8, 2019.
- ↑ Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, ACP; Speight, N; Vallings, R; Bateman, L; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Gerken, A; Jo, D; Lewis, DP; Light, AR; Light, KC; Marshall-Gradisnik, S; McLaren-Howard, J; Mena, I; Miwa, K; Murovska, M; Stevens, SR (2012), Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners (PDF), ISBN 978-0-9739335-3-6
- ↑ Carruthers, Bruce M.; Jain, Anil Kumar; De Meirleir, Kenny L.; Peterson, Daniel L.; Klimas, Nancy G.; Lerner, A. Martin; Bested, Alison C.; Flor-Henry, Pierre; Joshi, Pradip; Powles, AC Peter; Sherkey, Jeffrey A.; van de Sande, Marjorie I. (2003), "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols" (PDF), Journal of Chronic Fatigue Syndrome, 11 (2): 7–115, doi:10.1300/J092v11n01_02
