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Hydroxyproline is an amino acid and a major component of collagen. The formation of hydroxyproline is catalyzed via the enzyme procollagen-proline dioxygenase via a reaction that requires vitamin C.

Elevated plasma hydroxyproline is associated with increased risk of connective tissue injuries[1] and metabolic bone diseases.[2] Elevated levels of hydroxyproline, a marker of collagen breakdown, was found by Wenzhong Xiaoin the Severely Ill Patient Study.[3] Robert Naviaux’s work has suggested it as a possible biomarker for female ME/CFS patients.[4]

References[edit | edit source]

  1. Murguia, M.J.; Vailas, A.; Mandelbaum, B.; Norton, J.; Hodgdon, J.; Goforth, H.; Riedy, M. (Nov 1, 1988). "Elevated plasma hydroxyproline: A possible risk factor associated with connective tissue injuries during overuse". The American Journal of Sports Medicine. 16 (6): 660–664. doi:10.1177/036354658801600619. ISSN 0363-5465. 
  2. Mazzuoli, G.; Antonelli, R.; Minisola, S. (Sep 1985). "Clinical significance of free plasma hydroxyproline measurement in metabolic bone disease". Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie. 23 (9): 515–519. ISSN 0340-076X. PMID 4067520. 
  3. Open Medicine Foundation - OMF (Nov 7, 2018), Wenzhong Xiao, PhD | Results from the Severely Ill Patient Study (SIPS), retrieved Jul 16, 2019 
  4. Gordon, Eric; Anderson, Wayne; Nathan, Neil; Baxter, Asha; Wang, Lin; Alaynick, William A.; Bright, A. Taylor; Li, Kefeng; Naviaux, Jane C. (Sep 13, 2016). "Metabolic features of chronic fatigue syndrome". Proceedings of the National Academy of Sciences. 113 (37): E5472–E5480. doi:10.1073/pnas.1607571113. ISSN 0027-8424. PMID 27573827. 

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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.