From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Hydroxyproline is an amino acid and a major component of collagen.[1] The formation of hydroxyproline is catalyzed via the enzyme procollagen-proline dioxygenase via a reaction that requires vitamin C.[citation needed]

High plasma hydroxyproline[edit | edit source]

Elevated plasma hydroxyproline is associated with increased risk of connective tissue injuries[2] and metabolic bone diseases, e.g. osteoporosis.[3]

ME/CFS[edit | edit source]

Elevated levels of hydroxyproline, a marker of collagen breakdown, was found by Wenzhong Xiao in the ME/CFS Severely Ill, Big Data Study.[4] Robert Naviaux’s work has suggested it as a possible biomarker for female ME/CFS patients.[5]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. "Definition of HYDROXYPROLINE". Merrian-Webster Dictionary. Retrieved November 26, 2019.
  2. Murguia, M.J.; Vailas, A.; Mandelbaum, B.; Norton, J.; Hodgdon, J.; Goforth, H.; Riedy, M. (November 1, 1988). "Elevated plasma hydroxyproline: A possible risk factor associated with connective tissue injuries during overuse". The American Journal of Sports Medicine. 16 (6): 660–664. doi:10.1177/036354658801600619. ISSN 0363-5465.
  3. Mazzuoli, G.; Antonelli, R.; Minisola, S. (September 1985). "Clinical significance of free plasma hydroxyproline measurement in metabolic bone disease". Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie. 23 (9): 515–519. ISSN 0340-076X. PMID 4067520.
  4. Xiao, Wenzhong; Open Medicine Foundation - OMF (November 7, 2018), Results from the Severely Ill Patient Study (SIPS), retrieved July 16, 2019
  5. Gordon, Eric; Anderson, Wayne; Nathan, Neil; Baxter, Asha; Wang, Lin; Alaynick, William A.; Bright, A. Taylor; Li, Kefeng; Naviaux, Jane C. (September 13, 2016). "Metabolic features of chronic fatigue syndrome". Proceedings of the National Academy of Sciences. 113 (37): E5472–E5480. doi:10.1073/pnas.1607571113. ISSN 0027-8424. PMID 27573827.