From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Osteoporosis, a condition where bones thin and weaken, usually in older adults, resulting in increase risk of bone fractures, especially stress fractures. The risk of developing osteoporosis is considered higher in people with ME/CFS.[1]

A study in 2014, showed that patients without osteoporosis in the CFS cohort exhibited a 1.16-fold higher risk of fracture than did those in the non-CFS cohort. The researches concluded that although the cause remains unclear, CFS-related fracture might not be associated with osteoporosis.[2]

Presentation[edit | edit source]

Fractures and their causative and repair mechanisms have been topics subject to various forms of investigation for several decades.

Osteoporosis in ME/CFS[edit | edit source]

Possible causes[edit | edit source]

Potential treatments[edit | edit source]

Vitamin C can inhibit osteoporosis by promoting osteoblast formation and blocking osteoclastogenesis through the activation of signaling pathways. Therefore, it is suggested that vitamin C improves bone regeneration.[citation needed]

Notable studies[edit | edit source]

  • 2014, Chronic fatigue syndrome is associated with the risk of fracture: a nationwide cohort study[2] - (Full text)
  • 2019, Vitamin C Activates Osteoblastogenesis and Inhibits Osteoclastogenesis via Wnt/β-Catenin/ATF4 Signaling Pathways[citation needed]
  • 2019, Will the Elderly Benefit from a Fruit and Vegetable Nutritional Program? The Case of Vitamin C and Bone Health[citation needed]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. "Chronic Fatigue Syndrome and Osteoporosis". The Optimum Health Clinic. July 14, 2009. Retrieved October 10, 2019.
  2. 2.0 2.1 Kao, C.-H.; Kuo, C.-N.; Chen, H.-J.; Yang, T.-Y.; Lin, W.-M.; Chen, C.-S. (August 1, 2014). "Chronic fatigue syndrome is associated with the risk of fracture: a nationwide cohort study". QJM: An International Journal of Medicine. 107 (8): 635–641. doi:10.1093/qjmed/hcu037. ISSN 1460-2725.