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Osteoporosis, a condition where bones thin and weaken, usually in older adults, resulting in increase risk of bone fractures, especially stress fractures. The risk of developing osteoporosis is considered higher in people with ME/CFS.[1]

A study in 2014, showed that patients without osteoporosis in the CFS cohort exhibited a 1.16-fold higher risk of fracture than did those in the non-CFS cohort. The researches concluded that although the cause remains unclear, CFS-related fracture might not be associated with osteoporosis.[2]

Presentation[edit | edit source]

Fractures and their causative and repair mechanisms have been topics subject to various forms of investigation for several decades.

Osteoporosis in ME/CFS[edit | edit source]

Possible causes[edit | edit source]

Potential treatments[edit | edit source]

Vitamin C can inhibit osteoporosis by promoting osteoblast formation and blocking osteoclastogenesis through the activation of signaling pathways. Therefore, it is suggested that vitamin C improves bone regeneration.[citation needed]

Notable studies[edit | edit source]

  • 2014, Chronic fatigue syndrome is associated with the risk of fracture: a nationwide cohort study[2] - (Full text)
  • 2019, Vitamin C Activates Osteoblastogenesis and Inhibits Osteoclastogenesis via Wnt/β-Catenin/ATF4 Signaling Pathways[citation needed]
  • 2019, Will the Elderly Benefit from a Fruit and Vegetable Nutritional Program? The Case of Vitamin C and Bone Health[citation needed]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. "Chronic Fatigue Syndrome and Osteoporosis". The Optimum Health Clinic. Jul 14, 2009. Retrieved Oct 10, 2019. 
  2. 2.02.1 Kao, C.-H.; Kuo, C.-N.; Chen, H.-J.; Yang, T.-Y.; Lin, W.-M.; Chen, C.-S. (Aug 1, 2014). "Chronic fatigue syndrome is associated with the risk of fracture: a nationwide cohort study". QJM: An International Journal of Medicine. 107 (8): 635–641. doi:10.1093/qjmed/hcu037. ISSN 1460-2725. 

stress fracture - A tiny crack in a bone caused by repetitive forces such as running or by normal use of a bone that's weakened by a condition such as osteoporosis.

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

chronic fatigue syndrome (CFS) - A fatigue-based illness. The term CFS was invented invented by the U.S. Centers for Disease Control as an replacement for myalgic encephalomyelitis (ME). Some view CFS as a neurological disease, others use the term for any unexplained long-term fatigue. Sometimes used as a the term as a synonym of myalgic encephalomyelitis, despite the different diagnostic criteria.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.