Procollagen-proline dioxygenase (also known as protocollagen hydroxylase, prolyl hydroxylase, prolyl 4-hydroxylase and protocollagen prolyl hydroxylase) is an enzyme involved in collagen synthesis. It catalyzes the formation of hydroxyproline via the following, Vitamin C-dependent reaction:
procollagen L-proline + 2-oxoglutarate + O2 → (2S, 4R)-4-hydroxyproline + succinate + CO2
Some prolyl hydroxylases also act on hypoxia-inducible factors (HIFs) which are transcription factors that can modulate cellular metabolism under conditions of decreased oxygen.
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