Donald Lewis

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Dr Donald P. Lewis (died 29 July 2019) was a general practitioner specializing in ME/CFS in Melbourne, Australia. He had been treating patients with ME/CFS and researching the condition since his wife became ill with ME/CFS in 1985.[1]

International Consensus Criteria[edit | edit source]

Dr Lewis is one of the authors of the 2011 case definition, International Consensus Criteria.[2]

Books[edit | edit source]

  • Chronic Fatigue Syndrome/ME: Turning Disability Towards Ability (2003)
  • 2017, Chapter 31 - Sleep, Cognitive and Mood Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, in The Handbook of Stress and Health: A Guide to Research and Practice[3]

Notable studies[edit | edit source]

  • 2009, Increased d-lactic Acid intestinal bacteria in patients with chronic fatigue syndrome[4]
  • 2014, Comorbidity of postural orthostatic tachycardia syndrome and chronic fatigue syndrome in an Australian cohort[5]
  • 2015, Sleep quality and the treatment of intestinal microbiota imbalance in Chronic Fatigue Syndrome: A pilot study[6] - (Full text)
  • 2015, Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients[7]
  • 2016, Widespread pain and altered renal function in ME/CFS patients[8] - (Abstract)
  • 2016, Support for the Microgenderome: Associations in a Human Clinical Population[9] - (Full Text)
  • 2017, Examining clinical similarities between myalgic encephalomyelitis/chronic fatigue syndrome and d-lactic acidosis: a systematic review[10] - (Full Text)
  • 2017, The association of fecal microbiota and fecal, blood serum and urine metabolites in myalgic encephalomyelitis/chronic fatigue syndrome[11]
  • 2017, Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: a cross sectional study[12] - (Full text)
  • 2018, Weighting of orthostatic intolerance time measurements with standing difficulty score stratifies ME/CFS symptom severity and analyte detection[13]
  • 2018, Open-label pilot for treatment targeting gut dysbiosis in myalgic encephalomyelitis/chronic fatigue syndrome: neuropsychological symptoms and sex comparisons[14] - (Full Text) (Correction)
  • 2019, Post-Exertional Malaise Is Associated with Hypermetabolism, Hypoacetylation and Purine Metabolism Deregulation in ME/CFS Cases[15] - (Full text)
  • 2019, An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients[16] - (Abstract)

Clinic location[edit | edit source]

Dr Lewis founded the CFS Discovery clinic in Donvale, Melbourne, which has since closed.

Talks and interviews[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ "Trial By Error: My Interview with Melbourne's Dr Don Lewis". Virology blog. Retrieved August 21, 2019.
  2. ↑ Carruthers, Bruce M.; van de Sande, Marjorie I.; De Meirleir, Kenny L.; Klimas, Nancy G.; Broderick, Gordon; Mitchell, Terry; Staines, Donald; Powles, A.C. Peter; Speight, Nigel; Vallings, Rosamund; Bateman, Lucinda; Baumgarten-Austrheim, Barbara; Bell, David; Carlo-Stella, Nicoletta; Chia, John; Darragh, Austin; Jo, Daehyun; Lewis, Donald; Light, Alan; Marshall-Gradisnik, Sonya; Mena, Ismael; Mikovits, Judy; Miwa, Kunihisa; Murovska, Modra; Pall, Martin; Stevens, Staci (August 22, 2011). "Myalgic encephalomyelitis: International Consensus Criteria". Journal of Internal Medicine. 270 (4): 327–338. doi:10.1111/j.1365-2796.2011.02428.x. ISSN 0954-6820. PMC 3427890. PMID 21777306.
  3. ↑ Wallis, Amy; Jackson, Melinda L; Ball, Michelle; Lewis, Donald; Bruck, Dorothy (2017), Sleep, Cognitive and Mood Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, in The Handbook of Stress and Health: A Guide to Research and Practice, doi:10.1002/9781118993811.ch31
  4. ↑ Sheedy, John R; Wettenhall, Richard EH; Scanlon, Denis; Gooley, Paul R; Lewis, Donald P; McGregor, Neil; Stapleton, David I; Butt, Henry L; De Meirleir, Kenny L (July 2009), "Increased d-lactic Acid intestinal bacteria in patients with chronic fatigue syndrome", In Vivo, 23 (4): 621-8, PMID 19567398
  5. ↑ Reynolds, GK; Lewis, Donald P; Richardson, AM; Lidbury, Brett A (April 2014), "Comorbidity of postural orthostatic tachycardia syndrome and chronic fatigue syndrome in an Australian cohort", Journal of Internal Medicine, 275 (4): 409–417, doi:10.1111/joim.12161, PMID 24206536
  6. ↑ Jackson, Melinda L; Butt, Henry L; Ball, Michelle; Lewis, Donald P; Bruck, Dorothy (October 23, 2015), "Sleep quality and the treatment of intestinal microbiota imbalance in Chronic Fatigue Syndrome: A pilot study", Sleep Science, 8 (3): 124-33, doi:10.1016/j.slsci.2015.10.001, PMID 26779319
  7. ↑ Armstrong, Christopher W.; McGregor, Neil R.; Lewis, Donald P.; Butt, Henry L.; Gooley, Paul R. (2015), "Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients", Metabolomics, 11 (6): 1626–1639, doi:10.1007/s11306-015-0816-5
  8. ↑ McGregor, Neil R.; Armstrong, Christopher W.; Lewis, Donald P.; Butt, Henry L.; Gooley, Paul R. (July 2016). "Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients". Fatigue: Biomedicine, Health & Behavior. 4 (3): 132–145. doi:10.1080/21641846.2016.1207400.
  9. ↑ Wallis, Amy; Butt, Henry L; Ball, Michelle; Lewis, Donald P; Bruck, Dorothy (January 13, 2016), "Support for the Microgenderome: Associations in a Human Clinical Population", Scientific Reports, 6: 19171, doi:10.1038/srep19171, PMID 26757840
  10. ↑ Wallis, Amy; Ball, Michelle; McKechnie, Sandra; Butt, Henry L; Lewis, Donald P; Bruck, Dorothy (2017), "Examining clinical similarities between myalgic encephalomyelitis/chronic fatigue syndrome and d-lactic acidosis: a systematic review", Journal of Translational Medicine (15): 129, doi:10.1186/s12967-017-1229-1
  11. ↑ Armstrong, Christopher W.; McGregor, Neil R.; Lewis, Donald P.; Butt, Henry L.; Gooley, Paul R. (2017), "The association of fecal microbiota and fecal, blood serum and urine metabolites in myalgic encephalomyelitis/chronic fatigue syndrome", Metabolomics, 13 (1), doi:10.1007/s11306-016-1145-z
  12. ↑ Lidbury, Brett; Badia, Kita; Lewis, Donald; Hayward, Susan; Ludlow, Helen; Hedger, Mark; de Kretser, David (2017), "Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: a cross sectional study", Journal of Translational Medicine, doi:10.1186/s12967-017-1161-4
  13. ↑ Richardson, Alice; Lewis, Donald; Kita, Badia; Ludlow, Helen; Groome, Nigel; Hedger, Mark; de Kretser, David; Lidbury, Brett (2018), "Weighting of orthostatic intolerance time measurements with standing difficulty score stratifies ME/CFS symptom severity and analyte detection", Journal of Translational Medicine, 16: 97, doi:10.1186/s12967-018-1473-z
  14. ↑ Wallis, Amy; Ball, Michelle; Butt, Henry L; Lewis, Donald P; McKechnie, Sandra; Paull, Phillip; Jaa-Kwee, Amber; Bruck, Dorothy (2018). "Open-label pilot for treatment targeting gut dysbiosis in myalgic encephalomyelitis/chronic fatigue syndrome: neuropsychological symptoms and sex comparisons". Journal of Translational Medicine. 16 (1): 24. doi:10.1186/s12967-018-1392-z.
  15. ↑ McGregor, Neil R.; Armstrong, Christopher W.; Lewis, Donald P.; Gooley, Paul R. (July 4, 2019). "Post-Exertional Malaise Is Associated with Hypermetabolism, Hypoacetylation and Purine Metabolism Deregulation in ME/CFS Cases". Diagnostics. 9 (3): 70. doi:10.3390/diagnostics9030070. ISSN 2075-4418.
  16. ↑ Missailidis, Daniel; Annesley, Sarah; Allan, Claire; Sanislav, Oana; Lidbury, Brett; Lewis, Don; Fisher, Paul (September 4, 2019). "An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients". Preprints. doi:10.20944/preprints201909.0043.v1.
  17. ↑ Lewis, Donald P (May 2011), "Dr Don Lewis: Latest Understanding of ME/CFS (video)", Emerge Australia Seminar, Melbourne
  18. ↑ Lewis, Donald P; Guthridge, Mark (June 1, 2018), "What Do We Know About Chronic Fatigue Syndrome?", ABC Radio National (Australia) - Evenings with Christine Anu
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