Paul Gooley

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Source:ResearchGate

Paul Raymond Gooley, BSc, PhD, is an Associate Professor in Biochemistry and Molecular Biology and a researcher at the Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victoria, Australia since 1996.[1] He directs the Gooley Research Group at the Bio21 Molecular Science & Biotechnology Institute which specializes in nuclear magnetic resonance spectroscopy (NMR) in determining the structure and dynamics of small proteins. One of his research interests is the application of NMR methods in the exploration of metabolomics and the gut microbiome and its role in chronic fatigue syndrome.[2]

Education[edit | edit source]

  • 1982, BSc (Hon), University of New South Wales
  • 1985, PhD, University of New South Wales
  • 1987-1988, post-doctorate at Yale University

Books[edit | edit source]

  • 2014, Chapter Five in Advances in Clinical Chemistry, Vol. 66, published by Elsevier; "Metabolism in Chronic Fatigue Syndrome," by Christopher W. Armstrong, Neil R. McGregor, Henry L. Butt, and Paul R. Gooley[3] - (Full Text)

Notable studies[edit | edit source]

  • 2009, Increased d-lactic acid intestinal bacteria in patients with chronic fatigue syndrome[4] - (Full text)
  • 2012, NMR metabolic profiling of serum identifies amino acid disturbances in chronic fatigue syndrome[5] - (Abstract)
  • 2014, Metabolism in chronic fatigue syndrome[6] - (Abstract)
  • 2015, Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients[7] - (Abstract)
  • 2016, Widespread pain and altered renal function in ME/CFS patients[8] - (Abstract)
  • 2017, The association of fecal microbiota and fecal, blood serum and urine metabolites in myalgic encephalomyelitis/chronic fatigue syndrome[9] - (Abstract - Full test upon request)
  • 2019, Post-Exertional Malaise Is Associated with Hypermetabolism, Hypoacetylation and Purine Metabolism Deregulation in ME/CFS Cases[10] - (Full text)

Talks and interviews[edit | edit source]

Online presence[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ Flesch, Juliet (April 1, 2015). Transforming Biology: A History of the Department of Biochemistry and Molecular Biology at the University of Melbourne. Melbourne Univ. Publishing. ISBN 9780522867718.
  2. ↑ "Gooley Group". Bio21 Molecular Science & Biotechnology Institute. Retrieved July 11, 2019.
  3. ↑ Armstrong, CW; McGregor, NR; Butt, HL; Gooley, PR (October 2014), "Metabolism in chronic fatigue syndrome", Adv Clin Chem, 66: 121-72, doi:10.1016/B978-0-12-801401-1.00005-0, PMID 25344988
  4. ↑ Sheedy, John R.; Wettenhall, Richard E.H.; Scanlon, Denis; Gooley, Paul R.; Lewis, Donald P.; McGregor, Neil; Stapleton, David I.; Butt, Henry L.; De Meirleir, Kenny L. (July 2009). "Increased d-lactic Acid intestinal bacteria in patients with chronic fatigue syndrome". In Vivo (Athens, Greece). 23 (4): 621–628. ISSN 0258-851X. PMID 19567398.
  5. ↑ Armstrong, Christopher W.; McGregor, Neil R.; Sheedy, John R.; Buttfield, Ian; Butt, Henry L.; Gooley, Paul R. (2012), "NMR metabolic profiling of serum identifies amino acid disturbances in chronic fatigue syndrome", Clinica Chimica Acta, 413 (19–20): 1525–1531, doi:10.1016/j.cca.2012.06.022
  6. ↑ Armstrong, Christopher W.; McGregor, Neil R.; Butt, Henry L.; Gooley, Paul R. (2014). "Metabolism in chronic fatigue syndrome". Advances in Clinical Chemistry. 66: 121–172. ISSN 0065-2423. PMID 25344988.
  7. ↑ Armstrong, Christopher W.; McGregor, Neil R.; Lewis, Donald P.; Butt, Henry L.; Gooley, Paul R. (2015), "Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients", Metabolomics, 11 (6): 1626–1639, doi:10.1007/s11306-015-0816-5
  8. ↑ McGregor, Neil R.; Armstrong, Christopher W.; Lewis, Donald P.; Butt, Henry L.; Gooley, Paul R. (July 2016). "Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients". Fatigue: Biomedicine, Health & Behavior. 4 (3): 132–145. doi:10.1080/21641846.2016.1207400.
  9. ↑ Armstrong, Christopher W.; McGregor, Neil R.; Lewis, Donald P.; Butt, Henry L.; Gooley, Paul R. (2017), "The association of fecal microbiota and fecal, blood serum and urine metabolites in myalgic encephalomyelitis/chronic fatigue syndrome", Metabolomics, 13 (1), doi:10.1007/s11306-016-1145-z
  10. ↑ McGregor, Neil R.; Armstrong, Christopher W.; Lewis, Donald P.; Gooley, Paul R. (July 4, 2019). "Post-Exertional Malaise Is Associated with Hypermetabolism, Hypoacetylation and Purine Metabolism Deregulation in ME/CFS Cases". Diagnostics. 9 (3): 70. doi:10.3390/diagnostics9030070. ISSN 2075-4418.

The clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation. (Blood plasma is simply blood that has had its blood cells removed.)[1]

serum The clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation. (Blood plasma is simply blood that has had its blood cells removed.)

involving, related to or in the area of the kidneys[2]

renal involving, related to or in the area of the kidneys

microbiome The full collection of microscopic organisms (especially bacteria and fungi) which are present in a particular environment, particularly inside the human body.

serum The clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation. (Blood plasma is simply blood that has had its blood cells removed.)

metabolite A chemical compound produced by, or involved in, metabolism. The term is often used to refer to the degradation products of drugs in the body.

metabolomics The analysis of the chemical metabolism within cells, tissues or organisms. The term is often used to refer to the full set of metabolites found in a cell in a given environment.

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