Angiotensin I converting enzyme II

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Angiotensin I converting enzyme II or ACE2, also known as ACEH, is part of the renin-angiotensin system, which regulates blood pressure, and the balance of fluids and salts in the body.[1]

Function[edit | edit source]

The ACE2 encoding gene is believed to have a role in the carcardiovascular/circulatory system, kidney function, and fertility.[1][2]

ACE2 cuts the angiotensin I protein, convert it into angiotensin II.[1][2]

ME/CFS[edit | edit source]

Lieberman and Bell (1992) found higher serum ACE2 levels in 80% of patients with ME/CFS, compared to 9.4% of controls.[3]

POTS[edit | edit source]

Musafa et al. (2012) found some patients with POTS have "inappropriately high plasma angiotensin II levels", and estimated that these patents had low ACE2 activity.[4]

COVID-19[edit | edit source]

SARS-CoV-2, the virus that causes COVID-19, uses ACE2 receptors to binds to human cell.[5] Yan et al 2020) suggest that blocking ACE2 receptors may potentially prevent SARS-CoV-2 infection.[5]

Notable studies[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]