Angiotensin I converting enzyme II
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Angiotensin I converting enzyme II or ACE2, also known as ACEH, is part of the renin-angiotensin system, which regulates blood pressure, and the balance of fluids and salts in the body.[1]
Function[edit | edit source]
The ACE2 encoding gene is believed to have a role in the carcardiovascular/circulatory system, kidney function, and fertility.[1][2]
ACE2 cuts the angiotensin I protein, convert it into angiotensin II.[1][2]
ME/CFS[edit | edit source]
Lieberman and Bell (1992) found higher serum ACE2 levels in 80% of patients with ME/CFS, compared to 9.4% of controls.[3]
POTS[edit | edit source]
Musafa et al. (2012) found some patients with POTS have "inappropriately high plasma angiotensin II levels", and estimated that these patents had low ACE2 activity.[4]
COVID-19[edit | edit source]
SARS-CoV-2, the virus that causes COVID-19, uses ACE2 receptors to binds to human cell.[5] Yan et al 2020) suggest that blocking ACE2 receptors may potentially prevent SARS-CoV-2 infection.[5]
Notable studies[edit | edit source]
- 1992, Serum angiotensin-converting enzyme as a marker for the chronic fatigue-immune dysfunction syndrome: A comparison to serum angiotensin-converting enzyme in sarcoidosis
- 2012, Abnormalities of Angiotensin Regulation in Postural Tachycardia Syndrome
