Angiotensin-converting enzyme

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Angiotensin-converting enzyme or ACE is a non-specific enzyme involved in metabolizing many different peptides, and converts angiotensin I to angiotensin II (ACE2).[1]

Function[edit | edit source]

ACE drugs[edit | edit source]

ACE inhibitors[edit | edit source]

Angiotensin-converting enzyme inhibitors increase the level of ACE2. ACE inhibitors are one of several classes of drugs recommended for the initial treatment of hypertension, and are mainly used for high blood pressure and heart failure.[1][2]

ACE inhibitors include:

  • Captopril, a sulfur containing inhibitor
  • Benazepril (Lotensiin)
  • Cilazapril (Inhibace)
  • Enalapril (Vasotec, Epaned)
  • Fosinopril, a phosphorus containing inhibitor
  • Lisinopril (Prinivil, Zestril)
  • Moexipril (Univasc)
  • Perindopril (Aceon)
  • Quinapril (Accupril)
  • Ramipril (Altace)
  • Spirapril (Espirapril, Renormax)
  • Trandolapril (Mavik)
  • Zofenopril[2][1][3][4]

Recently, concerns have been expressed about the effect of ACE inhibitors in patients exposed to the SARS-CoV-2 virus which causes COVID-19 or the SARS-CoV virus that causes SARS.[5]

ME/CFS[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]