Talk:Brain

New study - brain stem connectivity

Added to Notable studies, but text needs adding to the page. From Queensland team, Fukuda criteria. ~Njt (talk) 08:20, October 28, 2019 (EDT)

• 2019,Intra brainstem connectivity is impaired in chronic fatigue syndrome

Hypoperfusion -- JenB (talk) 20:06, June 6, 2019 (EDT)

Interestingly, there is no mention on studies of hypoperfusion in CFS patients. This review article contains a number of references we might consider incorporating into this page: https://journals.sagepub.com/doi/pdf/10.1177/147323000803600501

--JenB (talk) 20:06, June 6, 2019 (EDT)

Images of Brain scans

If brain scans are needed them the following images are OK for copyright. Alternatively, Jarred Younger's video could be added using Insert, Template, Video - although images extracted from that video are not liicensed for reuse. I do not know which of the following show Neuroinflammation.

• File:Grey and white matter differences in Chronic Fatigue Syndrome (2017).jpeg
• File:Progressive_Brain_Changes_Longitudinal_MRI_Study_(2016).jpeg
• File:Brain-scan-CFS-basal-ganglia.png

notjusttired (talk) 16:30, September 4, 2019 (EDT)

The only images that directly show neuroinflammation are from the Japanese PET study. All the other images and studies only show subjective hints of neuroinflammation, but do NOT show neuroinflammation directly.

Pyrrhus (talk) 17:37, September 4, 2019 (EDT)

User:Notjusttired Here is an image we currently have that directly shows neuroinflammation: File:PK11195.gif

Pyrrhus (talk) 18:38, September 4, 2019 (EDT)

Useful diagrams

• File:8AE61DDE-341F-4D58-BE16-269F49B05CCE.jpeg
• File:Neuroinflammation-pathwayA.jpg

Helpful resource -- notjusttired (talk) 09:50, August 22, 2019 (EDT)

• Neuroimaging from ME Research UK

UNSORTED/unincorporated articles

• more abnormal spinal fluids, and psychiatric comorbidity does not influence any of these potential biological markers of CFS,
• a subgroup of CFS patients with brain abnormalities may have an underlying encephalopathy producing their illness.

• 2014, Brains of People With Chronic Fatigue Syndrome Offer Clues About Disorder By David Tuller - New York Times: Well

• 2016, One six year longitudinal study found that Chronic Fatigue Syndrome (CFS) (meeting the Fukuda criteria and Canadian Consensus Criteria) is associated with decreases in white matter, gray matter and blood volume deficits in the brain as compared to healthy controls. Full text)

• 2017, A study, using segmented anatomical MRI brain scans showed that, adjusting for total intracranial volume, CFS patients (as per Fukuda diagnostic criteria) had larger gray matter volume and lower white matter volume. The increased gray matter volume was predominantly found in the amygdala and insula cortex. The decreased white matter was predominantly found in the midbrain and temporal lobe. - (Full text)
• 2020, Exercise alters brain activation in (Full text) - see images folder
• 2022, Review of the Midbrain Ascending Arousal Network Nuclei (Full text)