Dr Donald P. Lewis is a general practitioner specialising in ME/CFS working in Melbourne, Australia. He has been treating patients with ME/CFS, and researching the condition, since 1985.
- 2017 - The association of fecal microbiota and fecal, blood serum and urine metabolites in myalgic encephalomyelitis/chronic fatigue syndrome
"Abstract - Introduction: The human gut microbiota has the ability to modulate host metabolism. Metabolic profiling of the microbiota and the host biofluids may determine associations significant of a host–microbe relationship. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a long-term disorder of fatigue that is poorly understood, but has been linked to gut problems and altered microbiota. Objectives: Find changes in fecal microbiota and metabolites in ME/CFS and determine their association with blood serum and urine metabolites. Methods: A workflow was developed that correlates microbial counts with fecal, blood serum and urine metabolites quantitated by high-throughput ¹H NMR spectroscopy. The study consists of thirty-four females with ME/CFS (34.9 ± 1.8 SE years old) and twenty-five non-ME/CFS female (33.0 ± 1.6 SE years old). Results: The workflow was validated using the non-ME/CFS cohort where fecal short chain fatty acids (SCFA) were associated with serum and urine metabolites indicative of host metabolism changes enacted by SCFA. In the ME/CFS cohort a decrease in fecal lactate and an increase in fecal butyrate, isovalerate and valerate were observed along with an increase in Clostridium spp. and a decrease in Bacteroides spp. These differences were consistent with an increase in microbial fermentation of fiber and amino acids to produce SCFA in the gut of ME/CFS patients. Decreased fecal amino acids positively correlated with substrates of gluconeogenesis and purine synthesis in the serum of ME/CFS patients. Conclusion: Increased production of SCFA by microbial fermentation in the gut of ME/CFS patients may be associated with deleterious effects on the host energy metabolism
- 2016, Widespread pain and altered renal function in ME/CFS patients
Abstract - "Background: Widespread pain is noted in many patients with chronic fatigue syndrome (ME/CFS), fibromyalgia and temporomandibular disorders. These conditions usually start as a localized condition and spread to a widespread pain condition with increasing illness duration. Purpose: To aim was to assess the changes in biochemistry associated with pain expression and alterations in renal function. Methods: Forty-seven ME/CFS patients and age/sex-matched controls had a clinical examination, completed questionnaires, standard serum biochemistry, glucose tolerance tests and serum and urine metabolomes in an observational study. Results: Increases in pain distribution were associated with reductions in serum essential amino acids, urea, serum sodium and increases in serum glucose and the 24-hour urine volume; however the biochemistry was different for each pain area. Regression modelling revealed potential acetylation and methylation defects in the pain subjects. Conclusions: These findings confirm and extend our earlier findings. These changes appear consistent with repeated minor inflammatory-mediated alterations in kidney function resulting in essential amino acid deprivation and inhibition of protein synthesis and genetic translation within tissues."
- 2016 - Support for the Microgenderome: Associations in a Human Clinical Population
- 2015 - Sleep quality and the treatment of intestinal microbiota imbalance in Chronic Fatigue Syndrome: A pilot study
- 2015 - Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients
- 2014 - Comorbidity of postural orthostatic tachycardia syndrome and chronic fatigue syndrome in an Australian cohort
- 2009 - Increased d-lactic Acid intestinal bacteria in patients with chronic fatigue syndrome
Dr Lewis founded the CFS Discovery clinic, which is in Donvale, Melbourne.
Talks & interviews
- 2011 - Dr Don Lewis: Latest Understanding of ME/CFS (video)
- Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, A C P; Speight, N; Vallings, R; Bateman, L; Baumgarten-Austrheim, B; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Jo, D; Lewis, D; Light, A; Marshall-Gradisnik, S; Mena, I; Mikovits, JA; Miwa, K; Murovska, M; Pall, ML; Stevens, S (2011), "Myalgic encephalomyelitis: International Consensus Criteria.", Journal of Internal Medicine, 270 (4): 327-38, PMID 21777306, doi:10.1111/j.1365-2796.2011.02428.x
- Armstrong, Christopher W.; McGregor, Neil R.; Lewis, Donald P.; Butt, Henry L.; Gooley, Paul R. (2017), "The association of fecal microbiota and fecal, blood serum and urine metabolites in myalgic encephalomyelitis/chronic fatigue syndrome", Metabolomics, 13 (1), doi:10.1007/s11306-016-1145-z
- McGregor, Neil R.; Armstrong, Christopher W.; Lewis, Donald P.; Butt, Henry L.; Gooley, Paul R. (2016), "Widespread pain and altered renal function in ME/CFS patients", Fatigue: Biomedicine, Health & Behavior, 4 (3): 132-145, doi:10.1080/21641846.2016.1207400
- Wallis, Amy; Butt, Henry L; Ball, Michelle; Lewis, Donald P; Bruck, Dorothy (13 Jan 2016), "Support for the Microgenderome: Associations in a Human Clinical Population", Scientific Reports, volume 6; article 19171, PMID 26757840, doi:10.1038/srep19171
- Jackson, Melinda L; Butt, Henry L; Ball, Michelle; Lewis, Donald P; Bruck, Dorothy (23 Oct 2015), "Sleep quality and the treatment of intestinal microbiota imbalance in Chronic Fatigue Syndrome: A pilot study", Sleep Science, 2015 Nov;8(3): 124-33, PMID 26779319, doi:10.1016/j.slsci.2015.10.001
- Armstrong, Christopher W.; McGregor, Neil R.; Lewis, Donald P.; Butt, Henry L.; Gooley, Paul R. (2015), "Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients", Metabolomics, 11 (6): 1626–1639, doi:10.1007/s11306-015-0816-5
- Reynolds, GK; Lewis, Donald P; Richardson, AM; Lidbury, Brett A (April 2014), "Comorbidity of postural orthostatic tachycardia syndrome and chronic fatigue syndrome in an Australian cohort", Journal of Internal Medicine, Volume 275, Issue 4: 409–417, PMID 24206536, doi:10.1111/joim.12161
- Sheedy, John R; Wettenhall, Richard EH; Scanlon, Denis; Gooley, Paul R; Lewis, Donald P; McGregor, Neil; Stapleton, David I; Butt, Henry L; De Meirleir, Kenny L (Jul 2009), "Increased d-lactic Acid intestinal bacteria in patients with chronic fatigue syndrome", In Vivo, 2009 Jul-Aug;23(4): 621-8, PMID 19567398
- Lewis, Donald P (May 2011), "Dr Don Lewis: Latest Understanding of ME/CFS (video)", Emerge Australia Seminar, Melbourne