Sirtuin 1

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Sirtuin 1 or SIRT1 refers to an enzyme or the gene encoded by the enzyme from the silent information regulator (Sir2)-like family.[1] Levels of SIRT1 expression may be associated with ME/CFS.

Other names[edit | edit source]

Sirtuin 1 is also known as

  • SIR2L1
  • NAD-Dependent Protein Deacetylase Sirtuin-1
  • NAD-Dependent Protein Deacylase Sirtuin-1
  • HSIRT1
  • HSIR2

Function[edit | edit source]

Sirtuins or silent information regulator (Sir2)-like family deacetylases are a group of enzymes found in the cytoplasm, mitochondria or nucleus of the cell and are ubiquitously expressed, and are closely related to histone deacetylases.[2] Their purpose in human disease is not well understood.[1]

ME/CFS[edit | edit source]

Notable studies[edit | edit source]

  • 2018, PO-132 Exogenous VD3 alleviates chronic fatigue syndrome by activating MEKs/ERKs-SIRT1 signaling pathway in skeletal muscle[3] - Conference proceedings (Abstract)
This refers to mice exhausted by excessive activity, which is an exclusion for chronic fatigue syndrome.
Results Compared with C group, CFS group appeared serious damage caused by fighting, and the concentration of serum testosterone decreased significantly (p<0.01 or p<0.05) while cortisol concentration increased significantly (p<0.01 or p<0.05). Regarding antioxidant stress system indexes, the expression of MDA, T-SOD and GSH-PX significantly increased (p<0.05). The concentration of MEK and SIRT3 decreased significantly (p<0.01 or p<0.05). Compared with CFS group, VD intervention group (bVD, mVD and aVD) showed less damage caused by fighting and significantly lighter body weight (p<0.05), and the concentration of serum testosterone increased significantly (p<0.05) while that of cortisol decreased significantly (p<0.01 or p<0.05). The expression of MDA decreased significantly (p<0.05), on the countrary, T-AOC, T-SOD and GSH-PX increased significantly (p<0.05). The expressions of MEK, p-ERK/ERK, SIRT1 and SIRT3 were significantly upregulated (p<0.01 or p<0.05).
  • 2016, Gene expression factor analysis to differentiate pathways linked to fibromyalgia, chronic fatigue syndrome, and depression in a diverse patient sample[4](Full text)
  • 2015, Novel Associations of F2-Isoprostanes, F3- Isoprostanes and Isofurans in Older Adults with Chronic Fatigue Syndrome: An Exploratory Study[5] - (Full Text)
  • 2011, Increased HDAC in association with decreased plasma cortisol in older adults with chronic fatigue syndrome[6](Full text)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.01.1 "SIRT1 gene". Gene cards. Retrieved March 18, 2022.
  2. "Class III HDACs (Sirtuins)". TOCRIS. Retrieved March 18, 2022.
  3. Wu, Fangnan; Huder, Chaolu; Tian, Zhenjun (October 4, 2018). "PO-132 Exogenous VD3 alleviates chronic fatigue syndrome by activating MEKs/ERKs-SIRT1 signaling pathway in skeletal muscle:". Exercise Biochemistry Review. 1 (4). doi:10.14428/ebr.v1i4.10353. ISSN 2593-7588.
  4. Iacob, E; Light, AR; Donaldson, GW; Okifuji, A; Hughen, RW; White, AT; Light, K (2016). "Gene expression factor analysis to differentiate pathways linked to fibromyalgia, chronic fatigue syndrome, and depression in a diverse patient sample". Arthritis Care and Research. 68 (1): 132-40. doi:10.1002/acr.22639. PMC 4684820. PMID 26097208.
  5. Kubow, Stan; Sorenson, Matthew; Alkazemi, Dalal; Roberts, Jackson L II; Adamski, Katherine Naselli; Jason, Leonard (2015). "Novel Associations of F2-Isoprostanes, F3- Isoprostanes and Isofurans in Older Adults with Chronic Fatigue Syndrome: An Exploratory Study" (PDF). Clinical Research: Open Access. 1: 1–4. doi:10.16966/clroa.103.
  6. Jason, Leonard; Sorenson, Matthew; Sebally, Kebba; Alkazemi, Dalal; Lerch, Athena; Porter, Nicole; Kubow, Stan (November 1, 2011). "Increased HDAC in association with decreased plasma cortisol in older adults with chronic fatigue syndrome". Brain, Behavior, and Immunity. 25 (8): 1544–1547. doi:10.1016/j.bbi.2011.04.007. ISSN 0889-1591.

enzyme a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.

enzyme a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.

serum The clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation. (Blood plasma is simply blood that has had its blood cells removed.)

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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.