Neuroimmune model

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The neuroimmune model or neuro immune hypothesis of ME/CFS proposes that an initial infection and immune activation, which can be caused by a number of different pathogens results in "a state of chronic peripheral immune activation driven by activated O&NS pathways that lead to progressive damage of self epitopes even when the initial infection has been cleared".[1]

The ATP deficiency, inflammation and oxidative and nitrosative stress are proposed to result from this, and to be the cause of the symptoms characteristic of ME/CFS.[1]

Theory[edit | edit source]

Evidence[edit | edit source]

Treatment[edit | edit source]

Notable studies and publications[edit | edit source]

  • 2011, Chronic fatigue syndrome – A neuroimmunological model[2](Full text)
  • 2013, A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome[1](Full text)
  • 2017, The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)[3](Full text)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

Myalgic encephalomyelitis or chronic fatigue syndrome


The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history