NTRK

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Neurotrophic Receptor Tyrosine Kinase or NTRK is a superfamily of receptor tyrosine kinases[1] these are protein-encoding genes that may be linked to myalgic encephalomyelitis/chronic fatigue syndrome.[2]

NTRK1[edit | edit source]

Neurotrophic Tyrosine Kinase Receptor 1 is one of the NTKR family of protein-encoding genes.[3]

ME/CFS[edit | edit source]

Almenar-Pérez et al (2020) found that NTRK appeared to be affected in patients with severe ME/CFS, which could relate to "symptoms such as cognitive disability and sensorial dysfunctions (altered pain sensitivity)44".[2] In this small study of patients with severe ME, NTRK1 levels were found to be significantly higher in the severely ill patients compared to healthy controls.[2]

Notable studies[edit | edit source]

  • Feb 7, 2020 - Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.[2]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. Thiriet, Marc (December 14, 2011). Signaling at the Cell Surface in the Circulatory and Ventilatory Systems. Springer Science & Business Media. p. 648. ISBN 978-1-4614-1991-4.
  2. 2.0 2.1 2.2 2.3 Almenar-Pérez, Eloy; Sarría, Leonor; Nathanson, Lubov; Oltra, Elisa (February 7, 2020). "Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Scientific Reports. 10 (1): 1–15. doi:10.1038/s41598-020-58506-5. ISSN 2045-2322. Retrieved February 12, 2020.
  3. GeneCards. "NTRK1 Gene | NTRK1 Protein | NTRK1 Antibody". genecards.org. Retrieved February 12, 2020.