Myelin basic protein

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Myelin basic proteins or MBP is a group of seven proteins produced from a single gene, and are found in the central and peripheral nervous system.[1] The gene encoding myelin basic protein is also referred to as MBP.[2]

Function[edit | edit source]

Myelin basic protein (MBP) is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin,[3] and MBP levels in cerebral spinal fluid are considered as a marker of active demyelination.[4][2]

ME/CFS[edit | edit source]

Notable studies[edit | edit source]

  • 2023, Catalytic Antibodies May Contribute to Demyelination in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[5] - (Full text)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. Achiron, A.; Miron, S. (January 1, 2007). "76 - MYELIN ASSOCIATED ANTIBODIES: MYELIN-ASSOCIATED GLYCOPROTEIN AUTOANTIBODIES, MYELIN BASIC PROTEIN AUTOANTIBODIES AND MYELIN PROTEOLIPID AUTOANTIBODIES IN NEUROLOGIC DISEASES". In Shoenfeld, Yehuda; Gershwin, M. Eric; Meroni, Pier Luigi (eds.). Autoantibodies (Second ed.). Burlington: Elsevier. pp. 619–626. ISBN 978-0-444-52763-9.
  2. 2.0 2.1 "MBP Gene - Myelin basic protein - Gene card". Gene cards. Retrieved December 31, 2023.
  3. Boggs, J. M. (September 1, 2006). "Myelin basic protein: a multifunctional protein". Cellular and Molecular Life Sciences CMLS. 63 (17): 1945–1961. doi:10.1007/s00018-006-6094-7. ISSN 1420-9071.
  4. "CSF myelin basic protein". Medline Plus Medical Encyclopedia. Retrieved December 30, 2023.
  5. Jensen, Michael Anthony; Dafoe, Miranda Lee; Wilhelmy, Julie; Cervantes, Layla; Okumu, Anna N.; Kipp, Lucas; Nemat-Gorgani, Mohsen; Davis, Ronald Wayne (November 27, 2023). "Catalytic Antibodies May Contribute to Demyelination in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Biochemistry. doi:10.1021/acs.biochem.3c00433. ISSN 1520-4995. PMID 38011893.