MTHFR and other methylation mutations
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According to Dr. David Kaufman of Open Medicine Institute, diagnostic biomarkers for ME/CFS include low natural killer cell function, low vasopressin levels, mutations of the MTHFR gene, and abnormalities of the Hypothalamic-pituitary-adrenal axis (HPA).
Note that by this definition, the infectious agent involved does not define the disease; indeed many people have many reactivated pathogens only revealed upon careful and reliable testing, including, herpesviruses, parvovirus B19, lyme, babesia, bartonella, etc.