Glial cell

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Glial cells, commonly called neuroglia or simply glia, are one of two major classes of cells in neural tissues, the other being neurons. Glia, which is Greek for glue, have traditionally been viewed as the glue that holds the neuronal system together, representing the historical view that glia exist to provide support to neurons. However, the type of glia known as microglia was subsequently found to actually be a tissue-resident macrophage, an immune cell. There is also increasing evidence that the type of glia known as astrocytes may play a more active role in brain function, by influencing and perhaps directing the activity of neurons (SFN 2000)."[1]

Glial activation[edit | edit source]

Glasson (2017) described the following model showing the effects of sustained glial activation.

Effects of sustained glial activation Source: Glassford JAG (2017) The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Front. Physiol. 8:88.[2]

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