Autophagy related gene 13

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Autophagy Related 13 or ATG13 is a gene that is involved in controlling autophagy.[1]

Function[edit | edit source]

ME/CFS[edit | edit source]

In May 2022, Simmaron Research announced that they were inserting several human genes including ATG13 into mice in order to research post-exertional malaise and fatigue.[2] ATG13 activates the myokines interleukin 6 (IL-6) and Regulated upon activation, normally T-expressed, and presumably secreted (RANTES).[2]

Notable studies[edit | edit source]

  • 2021, Molecular evidence of autophagy impairment as serum level of ATG13 is elevated in patients with myalgic encephalomyelitis and chronic fatigue syndrome: two independent case-control studies[3] - (Pre-print, Full text)
  • 2022, Elevated ATG13 in serum of patients with ME/CFS stimulates oxidative stress response in microglial cells via activation of receptor for advanced glycation end products (RAGE)[4] - (Abstract)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]