Regulatory T cell
Dietary and environmental factors[edit | edit source]
Vitamin D improves regulatory T cell function in healthy adults and in patients with relapsing remitting multiple sclerosis (MS), suggesting that it may play a role in both preventing and ameliorating autoimmune disease.
Chronic Fatigue Syndrome and ME/CFS[edit | edit source]
An Australian group found that Tregs were elevated in thirty individuals with Fukuda for chronic fatigue syndrome (CFS). The same group found elevated Tregs in a multiple sclerosis comparison study.
A second study in Japan also found decreased Tregs in 41 people who met both the Canadian Consensus Criteria and the International Consensus Criteria as compared to age- and gender-matched healthy controls.
It is worth noting that such seemingly contradictory results are often found in the systemic autoimmune diseases in which T cell subsets are often studied. Even in illnesses with well-established biomarkers, age, gender, and time since onset lead to significant variability.
Notable studies[edit | edit source]
- 2018, Association of T and NK Cell Phenotype With the Diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
- 2017, Dysregulation of T and B cells in myalgic encephalomyelitis/chronic fatigue syndrome
- 2016, Regulatory T, natural killer T and γδ T cells in multiple sclerosis and chronic fatigue syndrome/myalgic encephalomyelitis: a comparison.
See also[edit | edit source]
References[edit | edit source]
- Bock, Gerlies; Prietl, Barbara; Mader, Julia K.; Höller, Evelyne; Wolf, Michael; Pilz, Stefan; Graninger, Winfried B.; Obermayer-Pietsch, Barbara M.; Pieber, Thomas R. (Nov 2011). "The effect of vitamin D supplementation on peripheral regulatory T cells and β cell function in healthy humans: a randomized controlled trial". Diabetes/Metabolism Research and Reviews. 27 (8): 942–945. doi:10.1002/dmrr.1276. ISSN 1520-7560. PMID 22069289.
- Hupperts, Raymond; Damoiseaux, Jan; Tervaert, Jan Willem Cohen; Menheere, Paul; Peelen, Evelyn; Thewissen, Mariëlle; Smolders, Joost (Aug 13, 2009). "Vitamin D Status Is Positively Correlated with Regulatory T Cell Function in Patients with Multiple Sclerosis". PLOS ONE. 4 (8): e6635. doi:10.1371/journal.pone.0006635. ISSN 1932-6203. PMC . PMID 19675671.
- Issazadeh-Navikas, Shohreh; Teimer, Roman; Bockermann, Robert (Nov 16, 2011). "Influence of Dietary Components on Regulatory T Cells". Molecular Medicine. 18 (1): 95–110. doi:10.2119/molmed.2011.00311. ISSN 1076-1551. PMC . PMID 22113499.
- Brenu, Ekua Weba; Huth, Teilah K.; Hardcastle, Sharni L.; Fuller, Kirsty; Kaur, Manprit; Johnston, Samantha; Ramos, Sandra B.; Staines, Don R.; Marshall-Gradisnik, Sonya M. (Apr 2014). "Role of adaptive and innate immune cells in chronic fatigue syndrome/myalgic encephalomyelitis". International Immunology. 26 (4): 233–242. doi:10.1093/intimm/dxt068. ISSN 1460-2377. PMID 24343819.
- Ramos, S; Brenu, E; Broadley, S; Kwiatek, R; Ng, J; Nguyen, T; Freeman, S; Staines, D; Marshall-Gradisnik, S (Mar 20, 2016), "Regulatory T, natural killer T and γδ T cells in multiple sclerosis and chronic fatigue syndrome/myalgic encephalomyelitis: a comparison" (PDF), Asian Pac J Allergy Immunol, 2016 (34): 300-305, doi:10.12932/AP0733
- Rivas, Jose Luis; Palencia, Teresa; Fernández, Guerau; García, Milagros (May 9, 2018). "Association of T and NK Cell Phenotype With the Diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". Frontiers in Immunology. 9. doi:10.3389/fimmu.2018.01028. ISSN 1664-3224. PMC . PMID 29867995.
- Yamamura, T.; Sato, W.; Ono, H. (Oct 15, 2017). "Dysregulation of T and B cells in myalgic encephalomyelitis/chronic fatigue syndrome". Journal of the Neurological Sciences. 381: 899–900. doi:10.1016/j.jns.2017.08.2533. ISSN 0022-510X.
- Kasper, Isaac R.; Apostolidis, Sokratis A.; Sharabi, Amir; Tsokos, George C. (Sep 2016). "Empowering Regulatory T Cells in Autoimmunity". Trends in molecular medicine. 22 (9): 784–797. doi:10.1016/j.molmed.2016.07.003. ISSN 1471-4914. PMC . PMID 27461103.
chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.