The Clinical and Scientific Basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

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The Clinical and Scientific Basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, published as The Nightingale Research Foundation Review of The Clinical and Scientific Basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, as a classic book about myalgic encephalomyelitis by Dr Byron Hyde and other international experts.

The Clinical and Scientific Basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Editors Byron Hyde
Authors Jay Goldstein, Paul Levine
Country Canada, United States
Language English
Subject Medical reference, medical research
Genre Medical
Publisher Nightingale Research Foundation
Publication date
Media type print & digital
Pages 724
ISBN 978-0969566205, 0-9695662-0-4

The Clinical and Scientific Basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome is a large reference book edited by Byron Hyde, Jay Goldstein, and Paul Levine. The book contains the proceedings from the first international symposium for clinicians and researchers in ME/CFS, held in Cambridge, England in April 1990. The symposium was organized by Dr. Byron Hyde of the Nightingale Research Foundation and Dr. John Richardson of the Newcastle Research Group. One of the honorary chairpeople of the symposium, Dr. Melvin Ramsay, who was instrumental in encouraging the idea of the symposium, passed away a few weeks before the symposium was to be held. His prepared remarks were included in the book. From the forward to the book:

We have attempted to obtain material in every area of M.E./CFS knowledge, but we have not always been successful. Some information is under copyright and could not be released. Some promised material just never arrived. Scientific knowledge of M.E./CFS is growing so rapidly that we were not always able to keep up with all of the explosive changes in information. To compensate for some of the omissions, Nightingale staff have written review chapters only when an appropriate contributor was not available or the chapter was delayed. These review chapters represent Nightingale's opinions and are not necessarily those of the clinicians and researchers mentioned. Furthermore, in a few cases, we have requested and obtained permission from certain prestigious journals to reproduce works of historical significance. Due to the sheer length of some of the original manuscripts, it was necessary for us to reproduce some of the authors' work in abstract form.

A PDF of the book is freely available to download from the Nightingale Research Foundation website.[1]

Publisher's synopsis[edit | edit source]

(This synopsis was provided by the publisher for promotional purposes. For book reviews, please see Links section below.)

Eighty of the world's leading M.E./CFS authorities have contributed their knowledge to produce a 750-page encyclopedia on the disease process that may be one of the biggest single causes of chronic illness in the world today. Known in the United States as Chronic Fatigue Syndrome and in Great Britain both as Myalgic Encephalomyelitis and Post-Viral Fatigue Syndrome, M.E./CFS has provoked a chronic disabling illness in an estimated 1,000,000 persons in North America and Europe.

This book provides, in one superb 75-chapter source, an up-to-date, comprehensive account of current knowledge concerning the history, epidemiology, children with M.E., investigation, virology, immunology, muscle pathology, host response, food intolerance, brain mapping, neurophysiology, neuropsychology, psychiatry, sleep dysfunction, fibromyalgia syndrome, treatment and management.

This is an essential reference book for medical, government and public library reference rooms. This text is a unique vehicle for researchers, physicians and other health education and government officials, and is easily understandable by the general public interested in M.E./CFS.

Contents[edit | edit source]

  • i. Magnetic Resonance Imaging (MRI)
  • ii. Dedication: Dr. John Richardson
  • iv-viii. Brain Imaging Illustrations
  • ix. Foreword
  • x. Preface: Unravelling the Enigma
  • xiv. In Appreciation

Section 1: A Road Map to M.E. / CFS / PVFS / CFIDS[edit | edit source]

  • Chapter 1: The Disease of a Thousand Names
  • Chapter 2: The Definitions of M.E./CFS, A Review
  • Chapter 3: A Description of Patients, Borys Chabursky, Byron Hyde, M.D., Anil Jain, M.D.
  • Chapter 4: General Information, Post Infectious, Acute Onset M.E./CFS, Byron Hyde, M.D., Sheila Bastien, Ph.D, Anil Jain, M.D.
  • Chapter 5: Clinical Observations of CNS Dysfunction in Post-Infectious, Acute Onset M.E./CFS, Byron Hyde, M.D., Anil Jain, M.D.
  • Chapter 6: M.E./CFS: The Physical Signs of Disease, Byron Hyde, M.D., Anil Jain, M.D.

Section 2: Opening Remarks of the Honorary Chairmen[edit | edit source]

  • Chapter 7: Myalgic Encephalomyelitis, Then and Now, An Epidemiological Introduction, A. Melvin Ramsay, M.B., Betty Dowsett, M.B.
  • Chapter 8: M.E., The Epidemiological and Clinical Observations of a Rural Practitioner, John Richardson, M.B., B.S.

Section 3: Opening Remarks of some of the Chairmen[edit | edit source]

  • Chapter 9: The Myalgic Encephalomyelitis Syndrome, John Murdoch, M.D., Ph.D: New Zealand
  • Chapter 10: "Spasmophilia" and/or "Myalgic Encephalomyelitis", Henri Rubinstein, M.D.: France
  • Chapter 11: Tapanui Flu (A quest for a diagnosis), Peter Snow, M.B., ChB, FRNZCSP: New Zealand
Chairman J.E. Banatvala, MA., M.D., MRCP, FRCPath: England
Chairman Alan Smith, M.D.: South Africa

Section 4: An Historical Review of M.E./CFS Like Disease[edit | edit source]

  • Chapter 12: Myalgic Encephalomyelitis (Chronic Fatigue Syndrome): An Historical Perspective, Byron Hyde, M.D.

Section 5: The Twentieth Century History of M.E./CFS[edit | edit source]

Section 6: The Epidemiology and Methodology of M.E./CFS[edit | edit source]

  • Chapter 17: Epidemiolgic and Immunologic Findings in Clusters of Chronic Fatigue Syndrome, Seymour Grufferman, M.D., Dr. PH
  • Chapter 18: Epidemiologic Aspects of CFS/M.E., Paul H. Levine, M.D.

Section 7: Children and Students with M.E./CFS[edit | edit source]

  • Chapter 19: Children with M.E./CFIDS: Overview and Review of the Literature, David S. Bell, M.D., FAAP

Section 8: General Review[edit | edit source]

  • Chapter 20: A Multidisciplinary Approach to Investigating and Treating Patients with Chronic Fatigue, Richard H.T. Edwards, Ph.D., FRCP
  • Chapter 21: A Review of M.E. / CFIDS / PVFS in America, Anthony Komaroff, M.D.
  • Chapter 22: Post-Viral Fatigue Syndrome Research in Glasgow, A Review, Nightingale Research Foundation

Section 9: Evaluating the M.E./CFS Patient[edit | edit source]

  • Chapter 23: How do I Diagnose a Patient with Chronic Fatigue Syndrome?, Jay Goldstein, M.D.
  • Chapter 24: The Evaluation of Adults with Chronic Fatigue: A Review of Laboratory and Psychological Findings, Dedra Buchwald, M.D.
  • Chapter 25: Chronic Fatigue of Nasal Origin: Possible Confusion with Chronic Fatigue Syndrome, Alexander Chester III, M.D., FACP

Section 10: The Infectious Origins of M.E./CFS[edit | edit source]

  • Chapter 26: Possible Role for Epstein-Barr Virus (EBV) in the Chronic Fatigue Syndrome (CFS), James Jones, M.D.
  • Chapter 27: Detection of Viral Related Sequences in CFS Patients Using the Polymerase Chain Reaction, W. John Martin, M.D., Ph.D

Subsection A: The Enteroviral Theories[edit | edit source]

Subsection B: The Retroviral Theories[edit | edit source]

  • Chapter 33: A Retrovirus Aetiology for CFS?, Michael J. Holmes, M.D.
  • Chapter 34: Viral Infection in CFS Patients, W. John Martin, M.D., Ph.D
  • Chapter 35: The Search for a Retrovirus in CFS/CFIDS, Elaine DeFreitas, Ph.D, Hiroshi Terunuma, M.D., Ph.D.
  • Chapter 36: The Search for a Retrovirus in M.E./CFS, A Review, Byron Hyde, M.D.

Section 11: The Skeletal Muscle As Target[edit | edit source]

  • Chapter 37: Molecular Virology of Muscle Disease: Persistent Virus Infection of Muscle in Patients with Postviral Fatigue Syndrome, Leonard C. Archard, PhD, Louise Cunningham, Ph.D.
  • Chapter 38: Neuromuscular Abnormalities in Patients with CFS, Carolyn L. Warner, M.D. et al
  • Chapter 39: An Account of 100 Muscle Biopsies in Epidemic M.E., David Doyle, M.D.
  • Chapter 40: Whole Body and Muscle Protein Synthesis in Myalgic Encephalomyelitis, David Halliday, M.D., P.J. Pacy, M.D.
  • Chapter 41: Exercise Testing in Patients with Chronic Fatigue Syndrome, David McCluskey, M.D., M. Riley, M.D.

Section 12: The Heart As Target[edit | edit source]

  • Chapter 42: Cardiac and Cardiovascular Aspects of M.E./CFS, A Review, Byron Hyde, M.D., Anil Jain, M.D.

Section 13: Neurology[edit | edit source]

  • Chapter 43: The Differential Diagnosis Between Multiple Sclerosis and Chronic Fatigue Postviral Syndrome, Charles M. Poser, M.D.
  • Chapter 44: Neurological Features of M.E., Russell J.M. Lane, M.D.
  • Chapter 45: CFS: Limbic Encephalopathy in a Dysfunctional Neuroimmune Network, Jay Goldstein, M.D.

Section 14: M.E./CFS and the Peripheral Nervous System[edit | edit source]

  • Chapter 46: An Historical Review of the Electromyographic Features of Post-Infectious M.E./CFS, Byron Hyde, M.D., Alberto Marinacci, M.D. and Karl Von Hagen, M.D.
  • Chapter 47: Evidence for Organic Disturbance in the Post Viral Fatigue Syndrome: Neurophysiological Studies, Goran A. Jamal, M.D., Ph.D.

Section 15: M.E./CFS and Central Nervous System Injury[edit | edit source]

Section 16: Neuropsychological Changes in M.E./CFS[edit | edit source]

  • Chapter 51: Patterns of Neuropsychological Abnormalities and Cognitive Impairment in Adults and Children, Sheila Bastien, Ph.D
  • Chapter 52: The MMPI as an Aid to CFS Diagnosis, Linda Iger, Ph.D
  • Chapter 53: Is There a CFS Dementia?, Curt A. Sandman, Ph.D
  • Chapter 54: Physical and Psychosocial Functioning in Chronic Fatigue Syndrome, Diane L. Cookfair, Ph.D et al

Section 17: Psychiatry in M.E./CFS[edit | edit source]

  • Chapter 55: Depression / Somatization Explanations for the Chronic Fatigue Syndrome: A Critical Review, Donald G. Dutton, Ph.D
  • Chapter 56: The Psychiatric Status of Patients with the Chronic Fatigue Syndrome, Ian Hickie, M.D. et al

Section 18: Food Intolerance in M.E./CFS[edit | edit source]

Section 19: Immunology[edit | edit source]

  • Chapter 58: Immunological Abnormalities in Patients with CFS, Andrew Lloyd, M.D. et al
  • Chapter 59: Recent Developments in Immunological Aspects of CFS, Sudhir Gupta, M.D., Ph.D.
  • Chapter 60: Host Factors Affecting the Course and Outcome of Viral Disease, Roger M. Loria, Ph.D. (See also Chapter 74: The Role of Thymic Infections, Nathan Trainin, M.D. and Chapter 28: M.E. - A Persistent Enteroviral Infection, Betty Dowsett, M.D.)
  • Chapter 61: Abnormalities of Natural Killer (NK) Cell Numbers and Function in Patients with Chronic Fatigue Immune Dysfunction Syndrome (CFIDS), Hugh Pross, M.D., Ph.D, FRCPC

Section 20: Blood Cell Changes[edit | edit source]

  • Chapter 62: Opioid-Mediated Monocyte Dysfunction in the CFS, Jesus Prieto, M.D. et al
  • Chapter 63: Paired, Age, Sex and Ethnically Matched Studies of Peripheral Blood Leucocyte Profiles in Early CFS, Michael Holmes, M.D. et al
  • Chapter 64: Working Towards a Diagnostic Aid in CFS: Analysis of Peripheral Blood Leucocyte Profiles by Radial Plot, John Cross, Ph.D et al
  • Chapter 65: The Role of Nondiscocytic Erythrocytes in the Pathogenesis of M.E./CFS, Len O. Simpson, Ph.D.
  • Chapter 66: Differentiation Between M.S. and M.E., E.J. Field, M.D., FRCP

Section 21: New Investigation Techniques[edit | edit source]

  • Chapter 67: Biochemical Defects in the 2-5A Synthetase/RNAse L Pathway Associated with CFS with Encephalopathy, Robert J. Suhadolnik, Ph.D et al
  • Chapter 68: Evidence for T-Cell Activation by Soluble IL-2-R and T8-R in the Chronic Fatigue Syndrome, Paul R. Cheney, M.D., Ph.D (See also Chapter 64: Working Towards..., John Cross, Ph.D)

Section 22: Treatment[edit | edit source]

  • Chapter 69: Intravenous Immunoglobulin Therapy in Patients with CFS, Andrew Lloyd, M.D. et al
  • Chapter 70: Essential Fatty Acid Therapy for M.E., Michael D. Winther, M.D.
  • Chapter 71: Clinical Improvements Obtained with Ampligen in Patients with Severe CFS and Associated Encephalopathy, Daniel L. Peterson, M.D. et al
  • Chapter 72: Immunological Therapy with Transfer Factor, Andrew Lloyd, M.D. et al
  • Chapter 73: The Florence Nightingale Disease: A Multisystem Experiment of Nature: A 50 Patient Five Year Analysis, H. Hugh Fudenberg, M.D.
  • Chapter 74: The Role of Thymic Hormones in Viral Infections, Nathan Trainin, M.D. et al (See also Chapter 23: How I Diagnose..., Jay Goldstein, M.D.)

Section 23: Fibrositis / Fibromyalgia[edit | edit source]

  • Chapter 75: Fibrositis / Fibromyalgia Syndrome, I. Jon Russell, M.D., Ph.D

Section 24: Conclusions[edit | edit source]

Citation[edit | edit source]

Hyde, Byron, ed. (1992). The Nightingale Research Foundation Review of The Clinical and Scientific Basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Jay Goldstein, Paul Levine. Ottawa, Ontario, Canada: Nightingale Research Foundation. ISBN 978-0969566205.

Links[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. "Publications". Nightingale Research Foundation. Retrieved September 21, 2019.