Nuclear receptor subfamily 3 group C member 1

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NR3C1 or nuclear receptor subfamily 3, group C, member 1 or glucocorticoid receptor is a gene that may be associated with the development of chronic fatigue syndrome.[1][2]

Function[edit | edit source]

ME/CFS[edit | edit source]

Goertzel et al. (2006) concluded:

Three genes were found to be common in a group of people with Chronic Fatigue Syndrome compared to the general population; TPH2 - neuronal tryptophan hydroxylase, COMT - catechol-O-methyltransferase, and NR3C1 - nuclear receptor subfamily 3, group C, member 1 glucocorticoid receptor, together these three have an accuracy of 76%.[2]

Notable studies[edit | edit source]

  • 2006, Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes[2] - (Full text)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ "Nuclear receptor subfamily 3 group C member 1". Gene cards. Retrieved June 9, 2023.
  2. ↑ 2.02.12.2 Goertzel, Benjamin N.; Pennachin, Cassio; de Souza Coelho, Lucio; Gurbaxani, Brian; Maloney, Elizabeth M.; Jones, James F. (April 2006). "Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome". Pharmacogenomics. 7 (3): 475–483. doi:10.2217/14622416.7.3.475. ISSN 1462-2416. PMID 16610957.

accuracy The "closeness of an observation to the true clinical state". With respect to diagnostic tests, "accuracy" means how specific and sensitive the test is.

single nucleotide polymorphism (SNP) - A single nucleotide polymorphism (SNP, pronounced "snip") is a potential genetic mutation that occurs in a single spot in the human genome; a difference in a single DNA building block. SNPs are often represented by an "rs" number, such as "rs53576".

neuroendocrine relating to hormones that influence the nervous system

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