Nuclear receptor subfamily 3 group C member 1

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NR3C1 or nuclear receptor subfamily 3, group C, member 1 or glucocorticoid receptor is a gene that may be associated with the development of chronic fatigue syndrome.[1][2]

Function[edit | edit source]

ME/CFS[edit | edit source]

Goertzel et al. (2006) concluded:

Three genes were found to be common in a group of people with Chronic Fatigue Syndrome compared to the general population; TPH2 - neuronal tryptophan hydroxylase, COMT - catechol-O-methyltransferase, and NR3C1 - nuclear receptor subfamily 3, group C, member 1 glucocorticoid receptor, together these three have an accuracy of 76%.[2]

Notable studies[edit | edit source]

  • 2006, Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes[2] - (Full text)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. "Nuclear receptor subfamily 3 group C member 1". Gene cards. Retrieved June 15, 2024.
  2. 2.0 2.1 2.2 Goertzel, Benjamin N.; Pennachin, Cassio; de Souza Coelho, Lucio; Gurbaxani, Brian; Maloney, Elizabeth M.; Jones, James F. (April 2006). "Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome". Pharmacogenomics. 7 (3): 475–483. doi:10.2217/14622416.7.3.475. ISSN 1462-2416. PMID 16610957.