Glucocorticoid
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Glucocorticoid is a corticosteroid, often simply referred to as a steroid.
ME/CFS[edit | edit source]
Studies published in 2017 and 2018 by de Vega et al. found dysregulated glucocorticoid receptor function in people with ME/CFS. While glucocorticoids are anti-inflammatory in the periphery, they can be inflammatory to the central nervous system; these findings suggest this effect may be amplified in people with ME/CFS due to increased sensitivity to glucocorticoids.[1]
Studies[edit | edit source]
- 2000, Decreased bone mineral density during low dose glucocorticoid administration in a randomized, placebo controlled trial.[2] (Abstract)
- 2017, Epigenetic modifications and glucocorticoid sensitivity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)[3] (Full text)
References[edit | edit source]
- ↑ Seltzer, Jaime (June 19, 2019). "MEAction Research Summary 2019" (PDF). The MEAction Network. Retrieved July 5, 2019.
- ↑ McKenzie, R (September 2000). "Decreased bone mineral density during low dose glucocorticoid administration in a randomized, placebo controlled trial". Journal of Rheumatology. 27 (9): 2222–6.
- ↑ de Vega, Wilfred C.; Herrera, Santiago; Vernon, SuzanneD.; McGowan, Patrick O. (February 23, 2017). "Epigenetic modifications and glucocorticoid sensitivity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". BMC Medical Genomics. 10 (1): 11. doi:10.1186/s12920-017-0248-3. ISSN 1755-8794. Retrieved July 5, 2019.
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