Wilfred de Vega

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Wilfred Carlo de Vega, PhD, is a Business Development Specialist at Mitacs, Toronto, Canada. He completed his doctorate in the Department of Cell & Systems Biology at the University of Toronto, Canada, under the supervision of Dr. Patrick McGowan.

Doctorate thesis[edit | edit source]

  • 2018, DNA Methylation Modifications Associated with Glucocorticoid Sensitivity and Clinical Subtypes of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)[1] - De Vega's thesis research, supervised by under the supervision of Dr. Patrick McGowan,[2] examined genome-wide epigenetic changes associated with ME/CFS and how these changes have downstream consequences on stress hormone sensitivity which could potentially relate to clinical subtypes based on symptom severity. His thesis work and ME/CFS research in the McGowan lab were funded by the Solve ME/CFS Initiative, Natural Sciences and Engineering Research Council (NSERC), the Canadian Institutes of Health Research (CIHR), and the Falk Medical Research Foundation. (Abstract) (Full Text)

Publications related to ME/CFS[edit | edit source]

Talks and interviews[edit | edit source]

Online presence[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. de Vega, Wilfred Carlo (Jun 2018). "DNA Methylation Modifications Associated with Glucocorticoid Sensitivity and Clinical Subtypes of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". TSpace - University of Toronto Libraries. 
  2. "LinkedIn - Wilfred de Vega, PhD". July 2018. 
  3. de Vega, Wilfred C.; Vernon, Suzanne D.; McGowan, Patrick O. (August 2014). "DNA Methylation Modifications Associated with Chronic Fatigue Syndrome". PLoS ONE. 9 (8): e104757. doi:10.1371/journal.pone.0104757. 
  4. de Vega, Wilfred C.; McGowan, Patrick O. (2017), "The epigenetic landscape of myalgic encephalomyelitis/chronic fatigue syndrome: deciphering complex phenotypes", Epigenomics, 9 (11), doi:10.2217/epi-2017-0106 
  5. de Vega, Wilfred C.; Herrera, Santiago; Vernon, Suzanne D.; McGowan, Patrick O. (2017), "Epigenetic modifications and glucocorticoid sensitivity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)", BMC Med Genomics, 10 (11), doi:10.1186/s12920-017-0248-3 
  6. de Vega, Wilfred C.; Erdman, Lauren; Vernon, Suzanne D.; Goldenberg, Anna; McGowan, Patrick O. (2018), "Integration of DNA methylation & health scores identifies subtypes in myalgic encephalomyelitis/chronic fatigue syndrome", Epigenomics, 10 (5), doi:10.2217/epi-2017-0150 
  7. Herrera, S; de Vega, WC; Ashbrook, D; Vernon, SD; McGowan, PO (Dec 2018). "Genome-epigenome interactions associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Epigenetics. 13 (12): 1174–1190. doi:10.1080/15592294.2018.1549769. 
  8. "ME/CFS Canadian Collaborative Team Conference" (PDF). Retrieved Mar 11, 2019. 

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

genome - an organism’s complete set of DNA, including all of its genes

genome - an organism’s complete set of DNA, including all of its genes

epigenome - all of the chemical compounds that are not part of the DNA sequence, but are on or attached to DNA as a way to regulate genes activity

Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.