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Lipopolysaccharides (LPS) also known as lipoglycans and endotoxins are large molecules found on the outer membrane of gram-negative bacteria. They provoke a strong innate immune response. LPS is an exogenous pyrogen.

One study found higher levels of serum IgA and IgM against LPS in chronic fatigue syndrome patients, indicating bacterial translocation from the intestine into the bloodstream. [1]. Serum IgA was significantly correlated to the severity of illness.

A study of 128 ME/CFS patients found significantly increased IgA response to lipopolysaccharides (LPS) from the cell walls of commensal bacteria. Increased IgA response was associated with increased serum IL-1, TNFα, neopterin and elastase. The study concluded that increased translocation of commensal bacteria may be responsible for the disease activity in some ME/CFS patients.[2]

Some LPS molecules have been implicated in autoimmune disease including multiple sclerosis[3][4] and Guillain-Barré syndrome[5].

Vagus nerve stimulation may decrease the inflammatory response to LPS.[6]

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References[edit | edit source]

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.