Lipopolysaccharides (LPS) also known as lipoglycans and endotoxins are large molecules found on the outer membrane of gram-negative bacteria. They provoke a strong innate immune response. LPS is an exogenous pyrogen.
One study found higher levels of serum IgA and IgM against LPS in chronic fatigue syndrome patients, indicating bacterial translocation from the intestine into the bloodstream. . Serum IgA was significantly correlated to the severity of illness.
A study of 128 ME/CFS patients found significantly increased IgA response to lipopolysaccharides (LPS) from the cell walls of commensal bacteria. Increased IgA response was associated with increased serum IL-1, TNFα, neopterin and elastase. The study concluded that increased translocation of commensal bacteria may be responsible for the disease activity in some ME/CFS patients.
See also[edit | edit source]
References[edit | edit source]
- Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome, Maes M1, Twisk FN, Kubera M, Ringel K, Leunis JC, Geffard M., J Affect Disord. 2012 Feb;136(3):909-17. doi: 10.1016/j.jad.2011.09.010. Epub 2011 Oct 2.