Klaus Wirth

Professor Dr Klaus Josef Wirth is a medical doctor and Professor in Pharmacology at the Goethe University of Frankfurt, Germany and a researcher at KOSA Pharma GmbH.

Between 2020 and 2021, with Prof. Dr Carmen Scheibenbogen, Prof. Wirth published a set of articles describing a detailed hypothesis of the pathophysiology of ME/CFS.

Notable studies

• 2020, A Unifying Hypothesis of the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Recognitions from the finding of autoantibodies against ß2-adrenergic receptors - (Full text)
• 2021, An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - (Full text)
• 2021, Pathophysiology of skeletal muscle disturbances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - (Full text)
• 2024, Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence (ME/CFS) - (Full text)

Talks and interviews

• Video: Living with Chronic fatigue syndrome - German with English subtitles
• Video: Treating the Root Cause of Fatigue & PEM in Long Covid & ME/CFS: Mitodicure

Online presence

• PubMed
• Twitter
• Facebook
• LinkedIn
• Institution
• ORCID
• YouTube
• Address: clinic/lab-address

See also

• Wirth-Scheibenbogen hypothesis
• Carmen Scheibenbogen
• EUROMENE

Learn more

• Hypothesis Predicts Major Failure Point in Chronic Fatigue Syndrome (ME/CFS) - Health Rising (2021)

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

See myalgic encephalomyelitis.

See chronic fatigue syndrome.

autoantibody An antibody that works against the body's own antigens, a hallmark of autoimmune diseases. Autoantibodies are the opposite of an antibodies.