Wirth-Scheibenbogen hypothesis

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Prof Dr Klaus Wirth and Prof Dr Carmen Scheibenbogen

Theory[edit | edit source]

Hypothesis[edit | edit source]

Endothelial dysfunction is proposed to be key to ME/CFS, which is regarded as a neurovascular disease.[1][2][3]

Evidence[edit | edit source]

Treatment[edit | edit source]

Self-administered Immunoglobulin G (IgG) is a proposed treatment, with a proof of concept trial completed in 2021.[4]

Notable studies[edit | edit source]

  • 2021, An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[3] - (Full text)
  • 2021, Pathophysiology of skeletal muscle disturbances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)[2] - (Full text)
  • 2021, Tolerability and Efficacy of s.c. IgG Self-Treatment in ME/CFS Patients with IgG/IgG Subclass Deficiency: A Proof-of-Concept Study[4] - (Full text)
  • 2020, A Unifying Hypothesis of the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Recognitions from the finding of autoantibodies against ß2-adrenergic receptors[1] - (Full text)

Evidence and related studies[edit | edit source]

  • 2012, Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls[5] - (Full text)
  • 2011, Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome[6] - (Abstract)
  • 2009, Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects[7] - (Abstract)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ 1.0 1.1 Wirth, Klaus; Scheibenbogen, Carmen (June 1, 2020). "A Unifying Hypothesis of the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Recognitions from the finding of autoantibodies against ß2-adrenergic receptors". Autoimmunity Reviews. 19 (6): 102527. doi:10.1016/j.autrev.2020.102527. ISSN 1568-9972.
  2. ↑ 2.0 2.1 Wirth, Klaus J.; Scheibenbogen, Carmen (April 21, 2021). "Pathophysiology of skeletal muscle disturbances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". Journal of Translational Medicine. 19 (1): 162. doi:10.1186/s12967-021-02833-2. ISSN 1479-5876. PMC 8058748. PMID 33882940.
  3. ↑ 3.0 3.1 Wirth, Klaus J.; Scheibenbogen, Carmen; Paul, Friedemann (November 22, 2021). "An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Journal of Translational Medicine. 19 (1): 471. doi:10.1186/s12967-021-03143-3. ISSN 1479-5876. PMC 8607226. PMID 34809664.
  4. ↑ 4.0 4.1 Scheibenbogen, Carmen; Sotzny, Franziska; Hartwig, Jelka; Bauer, Sandra; Freitag, Helma; Wittke, Kirsten; Doehner, Wolfram; Scherbakov, Nadja; Loebel, Madlen; Grabowski, Patricia Grabowski (January 2021). "Tolerability and Efficacy of s.c. IgG Self-Treatment in ME/CFS Patients with IgG/IgG Subclass Deficiency: A Proof-of-Concept Study". Journal of Clinical Medicine. 10 (11): 2420. doi:10.3390/jcm10112420. PMC 8198960. PMID 34072494.
  5. ↑ White, Andrea T; Light, Alan R; Hughen, Ronald W; VanHaitsma, Timothy A; Light, Kathleen C (December 30, 2011). "Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls". Psychosom Med. 74 (1): 46-54. doi:10.1097/PSY.0b013e31824152ed. PMID 22210239.
  6. ↑ Light, Alan R; Bateman, Lucinda; Jo, Daehyun; Hughen, Ronald W; Vanhaitsma, TA; White, Andrea T; Light, Kathleen C (July 13, 2011). "Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome". J Intern Med. 271 (1): 64-81. doi:10.1111/j.1365-2796.2011.02405.x. PMID 21615807.
  7. ↑ Light, Alan R; White, Andrea T; Hughen, Ronald W; Light, Kathleen C (July 31, 2009). "Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects". J Pain. 10 (10): 1099-112. doi:10.1016/j.jpain.2009.06.003. PMID 19647494.
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