James F. Mowbray is a British doctor and professor of immunopathology who was affiliated with St Mary's Hospital Medical School in London. He is well known for co-editing a textbook on myalgic encephalomyelitis (ME) as well as for his work on developing an enterovirus antigen assay using the 5D8/1 monoclonal antibody against enterovirus VP1. This assay was previously used to demonstrate the presence of viral protein in the blood and brain tissue of British ME patients, and more recently has been used by Dr. John Chia to demonstrate viral presence in various tissues and organs of United States ME patients.
Book[edit | edit source]
References[edit | edit source]
- Post-viral Fatigue Syndrome (Myalgic Encephalomyelitis)
- Derivation and biochemical characterization of an enterovirus group-specific monoclonal antibody.
- Clinical and research application of an enterovirus group-reactive monoclonal antibody.
- "Infection may cause postviral syndrome". New Scientist. 117: 35. Jan 28, 1988.
Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.