Growth differentiation factor 15

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Growth Differentiation Factor 15 or GDF15 is a cytokine and circulating protein produced in the body in response to different stressors.[1][2] Circulating GDF15 levels are known to be highly elevated in mitochondrial disorders, which have early skeletal muscle fatigue as a key symptom.[2]

GDF15 in ME/CFS patients

Severe ME/CFS is associated with increased levels of GDF15, a circulating biomarker of cellular stress that appears which stable over several months.

Melvin et al. 2019

ME/CFS[edit | edit source]

Melvin et al. (2019) investigated where GDF15 could act as a potential biomarker of cellular stress in ME/CFS patients, finding that GDF15 levels were positively correlated with fatigue levels in ME/CFS patients.[2] The same study, which compared GDF15 levels in 50 patients with severe ME/CFS and 100 patients with mild/moderate ME/CFS, also found higher GDF15 levels in patients with ME/CFS than in patients with multiple sclerosis or healthy controls, with the more severely ill ME/CFS patients having the highest levels.[2]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. Zoltani, Csaba K. (2014). "Cardiovascular toxicity biomarkers". In Gupta, Ramesh C. Biomarkers in Toxicity. Boston: Academic Press. pp. 199–215. ISBN 978-0-12-404630-6. 
  2. Melvin, Audrey; Lacerda, Eliana; Dockrell, Hazel; O'Rahilly, Stephen; Nacul, Luis (Nov 27, 2019). "Circulating levels of GDF15 in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Journal of Translational Medicine. doi:10.17863/CAM.46401. ISSN 1479-5876. Retrieved Dec 1, 2019. 

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.