Deadlock quartet

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

The deadlock quartet is a combination of four nutrients used to overcome a proposed "deadlock" in the methylation cycle.[1][2]

The deadlock quartet consists of:

Theory[edit | edit source]

A hypotheical four-way "deadlock" in the methylation process is believed to cause energy limitations due to impaired metabolism.

Evidence[edit | edit source]

There is no peer-reviewed evidence in support of either a four-way deadlock in methylation or in the use of the deadlock quartet to treat it. The deadlock quartet was developed by Phoenix Rising forum member Freddd, based on work by ME/CFS patient Rich Van Konynenburg.[2]

The concept of a block or deadlock affecting energy metabolism is also part of the metabolic trap hypothesis, which was developed independently using the ME/CFS Severely Ill, Big Data Study, and which has different proposed treatments.[citation needed]

Clinicians[edit | edit source]

Risks and safety[edit | edit source]

Largely unknown since clinicial trials have not taken place. Cyanocobalamin has significant safety risks, including the loading of potassium levels.[3] Both cyanocobalamin and hydroxocobalamin are available as supplements and in other forms, including injections of higher doses as a perscription drug.[4][5] Allergies and anaphylatic shock also occur in some people given cyanocobalamin or other B12 forms.[3]

Costs and availability[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. Freddd (February 7, 2013). "Symptoms By Deadlock Quartet and other nutrients". Phoenix Rising. Retrieved May 19, 2022.
  2. 2.0 2.1 Van Konynenburg, Rich (September 19, 2009). "Status of methylation cycle model and treatment". Phoenix Rising. Retrieved May 19, 2022.
  3. 3.0 3.1 Paul, Cristiana; Brady, David M. (February 2017). "Comparative Bioavailability and Utilization of Particular Forms of B12 Supplements With Potential to Mitigate B12-related Genetic Polymorphisms". Integrative Medicine (Encinitas, Calif.). 16 (1): 42–49. ISSN 1546-993X. PMC 5312744. PMID 28223907.
  4. "Cyanocobalamin - FDA prescribing information, side effects and uses". Retrieved May 19, 2022.
  5. "Hydroxocobalamin injection Uses, Side Effects & Warnings". Retrieved May 19, 2022.