Alpha-lipoic acid

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Alpha-lipoic acid (ALA) is a chemical compound naturally found in the human body. It exists in two chemical forms, R-ALA and L-ALA, although only R-ALA is naturally found in the human body, in a protein-bound form.[1] It has sometimes been touted as an "antioxidant",[2] or a "chelator", although the biochemical context in which it naturally operates is much more complex than a simple solvated antioxidant or chelator. In its natural biochemical context, it serves as an important cofactor for many mitochondrial enzyme complexes.[3] In particular, it serves as a necessary cofactor for mitochondrial α-ketoacid dehydrogenases, performing a critical role in mitochondrial energy metabolism.[4] ALA in food sources is protein-bound, just as in the human body, which limits its ability to increase free-form ALA plasma levels upon ingestion.[5]

Alpha-lipoic acid is a cofactor for some of the key enzymes (alpha-keto acid dehydrogenase, pyruvate dehydrogenase, etc) involved in generating energy from food and oxygen in mitochondria and thus plays a critical role in energy production within the cell’s mitochondria.[5] Since one theory of CFS/ME is mitochondria dysfunction, supplementation may aid in energy production and reduce fatigue. Co-administration of ALA with other mitochondrial nutrients, such as acetyl-L-carnitine and coenzyme Q10, appears more effective in improving cognitive dysfunction and reducing oxidative mitochondrial dysfunction.[6]

Uses[edit | edit source]

In Germany lipoic acid has long been prescribed for diabetic neuropathy, cirrhosis, and mushroom and heavy metal poisonings.[7]

Lipoic acid can be administered intravenously. Supplemental oral ALA is 30-40% absorbed from the gastrointestinal tract. Supplemental forms often comprise a 50-50 mixture of R- and S-lipoic acid enantiomers. The R-form is better absorbed. Liquid formulas are also better absorbed.[8]

Side Effects[edit | edit source]

Supplementing ALA can result in nausea,malodorous urine, headache, weakness, pain, spams, and rash. Side effects are more commonly seen it higher doses.[7] It may interact with diabetic medications to cause hypoglycemia.

Clinical Trials[edit | edit source]

Diabetic Neuropathy[edit | edit source]

Meta-analyses of randomized controlled trials suggest that infusion of 300 to 600 mg/day of lipoic acid for 2 to 4 weeks significantly reduced symptoms of diabetic neuropathy.[9] A randomized, double-blind, placebo-controlled trial in 181 patients with diabetic neuropathy found that oral supplementation with either 600 mg/day, 1,200 mg/day, or 1,800 mg/day of lipoic acid for 5 weeks significantly improved neuropathic symptoms. There was no difference between the low, moderate or high dose groups.[10] Improvements in neuropathy from these trials are not always corroborated with electrodiagnostic testing. It is thought, that the beneficial effects of ALA on neuropathy may be due to effects on the small nerve fibers, making it a candidate treatment for small fiber neuropathy.[11]

Multiple Sclerosis[edit | edit source]

A small pilot study designed to evaluate the safety of lipoic acid in 30 people with relapsing or progressive multiple sclerosis found that treatment with 1,200 to 2,400 mg/day of oral lipoic acid for 2 weeks was safe. Those with the higher serum concentrations of lipoic acid had the lowest serum concentrations of MMP-9 — a marker of inflammation.[12] A 2-year trial of 1,200 mg/day LA in secondary progressive MS demonstrated a significant reduction of whole-brain atrophy and trend toward improvement in walking speed.[7]

References[edit | edit source]

  1. "Lipoic Acid". Linus Pauling Institute. Apr 28, 2014. Retrieved Dec 20, 2019. 
  2. Kaiser, Jon D. (2015). "A prospective, proof-of-concept investigation of KPAX002 in chronic fatigue syndrome". International Journal of Clinical and Experimental Medicine. 8 (7): 11064–11074. ISSN 1940-5901. PMC 4565289Freely accessible. PMID 26379906. 
  3. Ong, Sharon L. H.; Vohra, Harpreet; Zhang, Yi; Sutton, Matthew; Whitworth, Judith A. (2013). "The Effect of Alpha-Lipoic Acid on Mitochondrial Superoxide and Glucocorticoid-Induced Hypertension". Oxidative Medicine and Cellular Longevity. 2013: 1–9. doi:10.1155/2013/517045. ISSN 1942-0900. PMC 3600316Freely accessible. PMID 23533693. 
  4. Shay, Kate Petersen; Moreau, Régis F.; Smith, Eric J.; Smith, Anthony R.; Hagen, Tory M. (Oct 2009). "Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential". Biochimica et Biophysica Acta (BBA) - General Subjects. 1790 (10): 1149–1160. doi:10.1016/j.bbagen.2009.07.026. PMC 2756298Freely accessible. PMID 19664690. 
  5. 5.05.1 Park, Sungmi; Karunakaran, Udayakumar; Jeoung, Nam Ho; Jeon, Jae-Han; Lee, In-Kyu (2014). "Physiological effect and therapeutic application of alpha lipoic acid". Current Medicinal Chemistry. 21 (32): 3636–3645. doi:10.2174/0929867321666140706141806. ISSN 1875-533X. PMID 25005184. 
  6. Liu, Jiankang (Jan 2008). "The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview". Neurochemical Research. 33 (1): 194–203. doi:10.1007/s11064-007-9403-0. ISSN 0364-3190. PMID 17605107. 
  7. 7.07.17.2 Waslo, Carin; Bourdette, Dennis; Gray, Nora; Wright, Kirsten; Spain, Rebecca (May 6, 2019). "Lipoic Acid and Other Antioxidants as Therapies for Multiple Sclerosis". Current Treatment Options in Neurology. 21 (6): 26. doi:10.1007/s11940-019-0566-1. ISSN 1092-8480. PMID 31056714. 
  8. Uchida, Ryota; Okamoto, Hinako; Ikuta, Naoko; Terao, Keiji; Hirota, Takashi (Sep 21, 2015). "Enantioselective Pharmacokinetics of α-Lipoic Acid in Rats". International Journal of Molecular Sciences. 16 (9): 22781–22794. doi:10.3390/ijms160922781. ISSN 1422-0067. PMC 4613335Freely accessible. PMID 26402669. 
  9. Han, Tingting; Bai, Jiefei; Liu, Wei; Hu, Yaomin (Oct 2012). "A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy". European Journal of Endocrinology. 167 (4): 465–471. doi:10.1530/EJE-12-0555. ISSN 1479-683X. PMID 22837391. 
  10. Ziegler, Dan; Ametov, Alexander; Barinov, Alexey; Dyck, Peter J.; Gurieva, Irina; Low, Phillip A.; Munzel, Ullrich; Yakhno, Nikolai; Raz, Itamar (Nov 2006). "Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial". Diabetes Care. 29 (11): 2365–2370. doi:10.2337/dc06-1216. ISSN 0149-5992. PMID 17065669. 
  11. Swiecka, Marta; Maslinska, Maria; Kwiatkowska, Brygida (2018). "Small fiber neuropathy as a part of fibromyalgia or a separate diagnosis?" (PDF). International Journal of Clinical Rheumatology. 13 (6): 353–359. Retrieved Oct 29, 2019. 
  12. Yadav, V.; Marracci, G.; Lovera, J.; Woodward, W.; Bogardus, K.; Marquardt, W.; Shinto, L.; Morris, C.; Bourdette, D. (Apr 2005). "Lipoic acid in multiple sclerosis: a pilot study". Multiple Sclerosis (Houndmills, Basingstoke, England). 11 (2): 159–165. doi:10.1191/1352458505ms1143oa. ISSN 1352-4585. PMID 15794388. 

cofactor - A substance that acts with another substance to bring about certain effects. In biochemistry, a cofactor is a molecule that is necessary for a given biochemical reaction, but is not an enzyme or substrate of the reaction.

mitochondria - Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.

enzyme - a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.

enzyme - a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.

mitochondria - Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.

adverse reaction - Any unintended or unwanted response to the treatment under investigation in a clinical trial.

adverse reaction - Any unintended or unwanted response to the treatment under investigation in a clinical trial.

hypoglycemia - abnormal decrease of sugar in the blood

randomized controlled trial (RCT) - A trial in which participants are randomly assigned to two groups, with one group receiving the treatment being studied and a control or comparison group receiving a sham treatment, placebo, or comparison treatment.

double blinded trial - A clinical trial is double blinded if neither the participants nor the researchers know which treatment group they are allocated to until after the results are interpreted. This reduces bias. (Learn more: www.nottingham.ac.uk)

serum - The clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation. (Blood plasma is simply blood that has had its blood cells removed.)

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.