Citric acid cycle: Difference between revisions
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== Citric acid cycle in ME/CFS == | == Citric acid cycle in ME/CFS == | ||
A 2016 paper started to define how and why people with [[ME/CFS]] might experience poorly functioning [[cellular respiration]]<ref>{{Cite journal | last = Fluge|first = Øystein | last2 = Mella| first2 = Olav | last3 = Bruland|first3=Ove | last4 = Risa | first4 = Kristin | last5 = Dyrstad | first5 = Sissel E. | last6 = Alme | first6 = Kine | last7 = Rekeland|first7=Ingrid G. | last8 = Sapkota | first8 = Dipak | last9 = Røsland | first9 = Gro V.|date=2016-12-22|title=Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome | url =https://insight.jci.org/articles/view/89376|journal=JCI Insight|language=en|volume=1|issue=21|doi=10.1172/jci.insight.89376|issn=2379-3708}}</ref>while a review of published papers <ref>{{Cite journal | last = Filler|first = Kristin | last2 = Lyon| first2 = Debra | last3 = Bennett|first3=James | last4 = McCain | first4 = Nancy | last5 = Elswick | first5 = Ronald | last6 = Lukkahatai | first6 = Nada | last7 = Saligan|first7=Leorey N.|date=2014-04-13|title=Association of mitochondrial dysfunction and fatigue: A review of the literature | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136529/|journal=BBA Clinical|volume=1 | pages = 12–23|doi=10.1016/j.bbacli.2014.04.001|issn=2214-6474|pmc=4136529|pmid=25147756}}</ref> added empirical evidence of a relationship between mitochondrial dysfunction and fatigue. | A 2016 paper started to define how and why people with [[ME/CFS]] might experience poorly functioning [[cellular respiration]]<ref>{{Cite journal | last = Fluge|first = Øystein | last2 = Mella| first2 = Olav | last3 = Bruland | first3 = Ove | last4 = Risa | first4 = Kristin | last5 = Dyrstad | first5 = Sissel E. | last6 = Alme | first6 = Kine | last7 = Rekeland|first7=Ingrid G. | last8 = Sapkota | first8 = Dipak | last9 = Røsland | first9 = Gro V.|date=2016-12-22|title=Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome | url =https://insight.jci.org/articles/view/89376|journal=JCI Insight|language=en|volume=1|issue=21|doi=10.1172/jci.insight.89376|issn=2379-3708}}</ref>while a review of published papers <ref>{{Cite journal | last = Filler|first = Kristin | last2 = Lyon| first2 = Debra | last3 = Bennett | first3 = James | last4 = McCain | first4 = Nancy | last5 = Elswick | first5 = Ronald | last6 = Lukkahatai | first6 = Nada | last7 = Saligan|first7=Leorey N.|date=2014-04-13|title=Association of mitochondrial dysfunction and fatigue: A review of the literature | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136529/|journal=BBA Clinical|volume=1 | pages = 12–23|doi=10.1016/j.bbacli.2014.04.001|issn=2214-6474|pmc=4136529|pmid=25147756}}</ref> added empirical evidence of a relationship between mitochondrial dysfunction and fatigue. | ||
According to [[Ron Davis]], speaking at the 2016 [[IACFS/ME]] conference, "ME/CFS patients have a marked decrease in some of the Citric Acid Cycle metabolites while mitochondrial mutations generally cause an increase."<ref>{{Cite web|url=https://www.facebook.com/OpenMedicineFoundation/photos/a.332007933570301.63974.309364692501292/947648405339581/|title=Open Medicine Foundation | website = facebook.com|language=en|access-date=2018-10-09}}</ref> | According to [[Ron Davis]], speaking at the 2016 [[IACFS/ME]] conference, "ME/CFS patients have a marked decrease in some of the Citric Acid Cycle metabolites while mitochondrial mutations generally cause an increase."<ref>{{Cite web|url=https://www.facebook.com/OpenMedicineFoundation/photos/a.332007933570301.63974.309364692501292/947648405339581/|title=Open Medicine Foundation | website = facebook.com|language=en|access-date=2018-10-09}}</ref> | ||
Revision as of 02:36, October 14, 2022
The citric acid cycle (CAC) also known as the TCA cycle (tricarboxcylic acid cycle) or the Krebs cycle is a series of enzyme-catalyzed chemical reactions that allow for aerobic respiration to occur within the mitochondria of the cell. When this cycle or its associated parts[1] are not functioning properly subsequent fatigue may take place.
Citric acid cycle in ME/CFS[edit | edit source]
A 2016 paper started to define how and why people with ME/CFS might experience poorly functioning cellular respiration[2]while a review of published papers [3] added empirical evidence of a relationship between mitochondrial dysfunction and fatigue.
According to Ron Davis, speaking at the 2016 IACFS/ME conference, "ME/CFS patients have a marked decrease in some of the Citric Acid Cycle metabolites while mitochondrial mutations generally cause an increase."[4]
Learn more[edit | edit source]
- Wikipedia - Citric acid cycle
- Krebs / citric acid cycle | Cellular respiration | tricarboxylic acid cycle| Biology | Khan Academy[5]
See also[edit | edit source]
References[edit | edit source]
- ↑ "Pyruvate Dehydrogenase Complex".
- ↑ Fluge, Øystein; Mella, Olav; Bruland, Ove; Risa, Kristin; Dyrstad, Sissel E.; Alme, Kine; Rekeland, Ingrid G.; Sapkota, Dipak; Røsland, Gro V. (December 22, 2016). "Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome". JCI Insight. 1 (21). doi:10.1172/jci.insight.89376. ISSN 2379-3708.
- ↑ Filler, Kristin; Lyon, Debra; Bennett, James; McCain, Nancy; Elswick, Ronald; Lukkahatai, Nada; Saligan, Leorey N. (April 13, 2014). "Association of mitochondrial dysfunction and fatigue: A review of the literature". BBA Clinical. 1: 12–23. doi:10.1016/j.bbacli.2014.04.001. ISSN 2214-6474. PMC 4136529. PMID 25147756.
- ↑ "Open Medicine Foundation". facebook.com. Retrieved October 9, 2018.
- ↑ "Krebs / citric acid cycle | Cellular respiration | Biology | Khan Academy". YouTube. Khan Academy. December 11, 2009.
