Growth differentiation factor 15: Difference between revisions
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'''Growth Differentiation Factor 15''' or '''GDF15''' is a [[cytokine]] and circulating protein produced in the body in response to different stressors.<ref name="Toxicology2014">{{Cite book|last=Zoltani|first=Csaba K.|author-link=|date=2014|editor-last=Gupta|editor-first=Ramesh C.|title=Biomarkers in Toxicity|url=http://www.sciencedirect.com/science/article/pii/B9780124046306000117|chapter=Cardiovascular toxicity biomarkers|location=Boston|publisher=Academic Press|pages=199–215|doi=|isbn=978-0-12-404630-6|access-date=|quote=|via=}}</ref><ref name="Melvin2019" /> Circulating GDF15 levels are known to be highly elevated in [[Mitochondrial disorder|mitochondrial disorders]], which have early skeletal muscle fatigue as a key symptom.<ref name="Melvin2019" /> | '''Growth Differentiation Factor 15''' or '''GDF15''' is a [[cytokine]] and circulating protein produced in the body in response to different stressors.<ref name="Toxicology2014">{{Cite book|last=Zoltani|first=Csaba K.|author-link=|date=2014|editor-last=Gupta|editor-first=Ramesh C.|title=Biomarkers in Toxicity|url=http://www.sciencedirect.com/science/article/pii/B9780124046306000117|chapter=Cardiovascular toxicity biomarkers|location=Boston|publisher=Academic Press|pages=199–215|doi=|isbn=978-0-12-404630-6|access-date=|quote=|via=}}</ref><ref name="Melvin2019" /> Circulating GDF15 levels are known to be highly elevated in [[Mitochondrial disorder|mitochondrial disorders]], which have early skeletal muscle fatigue as a key symptom.<ref name="Melvin2019" /> | ||
{{Quote box|Severe ME/CFS is associated with increased levels of GDF15, a circulating biomarker of cellular stress that appears which stable over several months.|title=GDF15 in ME/CFS patients|source=Melvin et al. 2019}} | |||
==ME/CFS== | ==ME/CFS== | ||
Revision as of 17:43, January 13, 2020
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Growth Differentiation Factor 15 or GDF15 is a cytokine and circulating protein produced in the body in response to different stressors.[1][2] Circulating GDF15 levels are known to be highly elevated in mitochondrial disorders, which have early skeletal muscle fatigue as a key symptom.[2]
Severe ME/CFS is associated with increased levels of GDF15, a circulating biomarker of cellular stress that appears which stable over several months.
ME/CFS[edit | edit source]
Melvin et al. (2019) investigated where GDF15 could act as a potential biomarker of cellular stress in ME/CFS patients, finding that GDF15 levels were positively correlated with fatigue levels in ME/CFS patients.[2] The same study, which compared GDF15 levels in 50 patients with severe ME/CFS and 100 patients with mild/moderate ME/CFS, also found higher GDF15 levels in patients with ME/CFS than in patients with multiple sclerosis or healthy controls, with the more severely ill ME/CFS patients having the highest levels.[2]
Learn more[edit | edit source]
See also[edit | edit source]
References[edit | edit source]
- ↑ Zoltani, Csaba K. (2014). "Cardiovascular toxicity biomarkers". In Gupta, Ramesh C. (ed.). Biomarkers in Toxicity. Boston: Academic Press. pp. 199–215. ISBN 978-0-12-404630-6.
- ↑ 2.0 2.1 2.2 2.3 Melvin, Audrey; Lacerda, Eliana; Dockrell, Hazel; O'Rahilly, Stephen; Nacul, Luis (November 27, 2019). "Circulating levels of GDF15 in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Journal of Translational Medicine. doi:10.17863/CAM.46401. ISSN 1479-5876. Retrieved December 1, 2019.
