Growth differentiation factor 15: Difference between revisions
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==ME/CFS== | ==ME/CFS== | ||
Melvin et al. (2019) investigated GDF15 could act as a potential [[biomarker]] of cellular stress in [[ME/CFS]] patients, finding that GDF15 levels were positively correlated with fatigue levels in ME/CFS patients.<ref name="Melvin2019" /> The same study, which compared GDF15 levels in 50 patients with severe ME/CFS and 100 patients with mild/moderate ME/CFS, also found higher GDF15 levels in patients with ME/CFS than in patients with [[multiple sclerosis]] or healthy controls, with the more severely ill ME/CFS patients having the highest levels.<ref name="Melvin2019">{{Cite journal|last=Melvin|first=Audrey|author-link=Audrey Melvin|last2=Lacerda|first2=Eliana|author-link2=Eliana Lacerda|last3=Dockrell|first3=Hazel|author-link3=Hazel Dockrell|last4=O'Rahilly|first4=Stephen|author-link4=Stephen O'Rahilly|last5=Nacul|first5=Luis|author-link5=Luis Nacul|last6=|first6=|author-link6=|last7=|first7=|last8=|first8=|date=2019-11-27|title=Circulating levels of GDF15 in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|url=https://www.repository.cam.ac.uk/handle/1810/299333|journal=Journal of Translational Medicine|language=en|volume=|issue=|pages=|doi=10.17863/CAM.46401|issn=1479-5876|pmc=|pmid=|access-date=Dec 1, 2019|quote=|via=}}</ref> | Melvin et al. (2019) investigated where GDF15 could act as a potential [[biomarker]] of cellular stress in [[ME/CFS]] patients, finding that GDF15 levels were positively correlated with fatigue levels in ME/CFS patients.<ref name="Melvin2019" /> The same study, which compared GDF15 levels in 50 patients with severe ME/CFS and 100 patients with mild/moderate ME/CFS, also found higher GDF15 levels in patients with ME/CFS than in patients with [[multiple sclerosis]] or healthy controls, with the more [[Severe and very severe ME|severely ill ME/CFS patients]] having the highest levels.<ref name="Melvin2019">{{Cite journal|last=Melvin|first=Audrey|author-link=Audrey Melvin|last2=Lacerda|first2=Eliana|author-link2=Eliana Lacerda|last3=Dockrell|first3=Hazel|author-link3=Hazel Dockrell|last4=O'Rahilly|first4=Stephen|author-link4=Stephen O'Rahilly|last5=Nacul|first5=Luis|author-link5=Luis Nacul|last6=|first6=|author-link6=|last7=|first7=|last8=|first8=|date=2019-11-27|title=Circulating levels of GDF15 in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|url=https://www.repository.cam.ac.uk/handle/1810/299333|journal=Journal of Translational Medicine|language=en|volume=|issue=|pages=|doi=10.17863/CAM.46401|issn=1479-5876|pmc=|pmid=|access-date=Dec 1, 2019|quote=|via=}}</ref> | ||
==Learn more== | ==Learn more== | ||
Revision as of 17:40, January 13, 2020
 | This article is a stub. |
Growth Differentiation Factor 15 or GDF15 is a cytokine and circulating protein produced in the body in response to different stressors.[1][2] Circulating GDF15 levels are known to be highly elevated in mitochondrial disorders, which have early skeletal muscle fatigue as a key symptom.[2]
ME/CFS[edit | edit source]
Melvin et al. (2019) investigated where GDF15 could act as a potential biomarker of cellular stress in ME/CFS patients, finding that GDF15 levels were positively correlated with fatigue levels in ME/CFS patients.[2] The same study, which compared GDF15 levels in 50 patients with severe ME/CFS and 100 patients with mild/moderate ME/CFS, also found higher GDF15 levels in patients with ME/CFS than in patients with multiple sclerosis or healthy controls, with the more severely ill ME/CFS patients having the highest levels.[2]
Learn more[edit | edit source]
See also[edit | edit source]
References[edit | edit source]
- ↑ Zoltani, Csaba K. (2014). "Cardiovascular toxicity biomarkers". In Gupta, Ramesh C. (ed.). Biomarkers in Toxicity. Boston: Academic Press. pp. 199–215. ISBN 978-0-12-404630-6.
- ↑ 2.0 2.1 2.2 2.3 Melvin, Audrey; Lacerda, Eliana; Dockrell, Hazel; O'Rahilly, Stephen; Nacul, Luis (November 27, 2019). "Circulating levels of GDF15 in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Journal of Translational Medicine. doi:10.17863/CAM.46401. ISSN 1479-5876. Retrieved December 1, 2019.
