Rofecoxib

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Rofecoxib is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). It is no longer available, having been voluntarily withdrawn from the market.[1]

Withdrawn from sale[edit | edit source]

In 2004, rofecoxib was voluntarily withdrawn from sale by manufacturer Merck because of safety concerns about the increased risk of stroke and heart attack when high doses are used for the long term.[1]

Side effects[edit | edit source]

Using nonsteroidal anti-inflammatory precautions is recommended to avoid gastrointestinal side effects. Hepatic and renal dysfunction may occur, and peripheral edema.[2]Central nervous system side effects include "dizziness, headaches, drowsiness and evidence of hypersensitives." [2]

More commonly reported ones are:

  • Gastrointestinal side-effects including bleeding.[2]

More commonly reported ones in children are:


Less commonly reported ones are:

Evidence[edit | edit source]

Before being withdrawn from the market Rofecoxib was listed as a suggested drug in the Canadian Consensus Criteria for ME/CFS, but it was not highlighted as better in any way in comparison to celecoxib or other NSAIDs.[2]

Dose[edit | edit source]

A dose of 12.5 to 25 mg daily, if needed, was suggested by the Canadian Consensus Criteria.[2]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]


adverse reaction - Any unintended or unwanted response to the treatment under investigation in a clinical trial.

adverse reaction - Any unintended or unwanted response to the treatment under investigation in a clinical trial.

renal - involving, related to or in the area of the kidneys

Canadian Consensus Criteria (CCC) - A set of diagnostic criteria used to diagnose ME/CFS, developed by a group of practicing ME/CFS clinicians in 2003. The CCC is often considered to be the most complex criteria, but possibly the most accurate, with the lowest number of patients meeting the criteria. Led to the development of the International Consensus Criteria (ICC) in 2011.

chronic fatigue syndrome (CFS) - A fatigue-based illness. The term CFS was invented invented by the U.S. Centers for Disease Control as an replacement for myalgic encephalomyelitis (ME). Some view CFS as a neurological disease, others use the term for any unexplained long-term fatigue. Sometimes used as a the term as a synonym of myalgic encephalomyelitis, despite the different diagnostic criteria.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.