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Two-day cardiopulmonary exercise testing or 2-day CPET is a of post-exertional malaise (PEM), one of the cardinal symptoms that distinguishes between individuals with and without ME/CFS. The hypothesis is that ME/CFS patients are almost unique in having a severe deterioration in the second of the two cardiopulmonary exercise tests performed on consecutive days. The test is also frequently used in research to compare outcomes pre- and post- exercise. (more...)

post-exertional malaise (PEM) - A notable exacerbation of symptoms brought on by small physical or cognitive exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others.

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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.