PACE Trial Management Group

The PACE Trial Management Group is credited as an author of the PACE trial. It was responsible for the day-to-day running and management of the trial and met periodically throughout the design, implementation, and publication of the study.

Group members

Chair

• Peter D. White, MD, Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine, Queen Mary University of London, London, UK (Also served as a principal investigator)

Principal investigators

• Peter D. White, MD, Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine, Queen Mary University of London, London, UK (Also served as the PACE Trial Management Group Chair)

• Trudie Chalder, PhD, Academic Department of Psychological Medicine, King's College London, London, UK (Also was a centre leader)

• Michael Sharpe, MD, Psychological Medicine Research, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK

Centre leaders

• Brian J. Angus, MD, Nuffield Department of Medicine, University of Oxford, The John Radcliffe Hospital, Oxford, UK

• Trudie Chalder, PhD, Academic Department of Psychological Medicine, King's College London, London, UK (Also served as a principal investigator)

• Eleanor Feldman, MRCPsyc, University of Oxford, Dept of Psychological Medicine, Barnes Unit, John Radcliffe Hospital, Headington, Oxford, UK

• Gabrielle Murphy, MSc, Royal Free Hospital NHS Trust, London, UK

• Maurice Murphy, FRCP, Barts and the London NHS Trust, London, UK

• Hazel O'Dowd, PhD, Frenchay Hospital NHS Trust, Bristol, UK

• Tim Peto, RCP, Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford, UK

• Michael Sharpe, MD, Psychological Medicine Research, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK (Also served as a principal investigator)

• Peter D. White, MD, Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine, Queen Mary University of London, London, UK (Also served as Chair and a principal investigator)

• David Wilks, FRCP[Ed], Western General Hospital, Edinburgh, UK

• Simon Wessely M.A., M.Sc., M.D., F.R.C.P., M.R.C.Psych., psychiatrist, King's College London, President of the Royal College of Psychiatrists

Treatment leaders

• Jessica Bavinton, BSc, Barts and the London NHS Trust, London, UK

• Mary Burgess, PhD, South London and Maudsley NHS Foundation Trust, London, UK

• Diane L. Cox, PhD, Faculty of Health and Well Being, University of Cumbria, Lancaster, UK

• Gabrielle Murphy, MSc, Royal Free Hospital NHS Trust, London, UK (Also served as a centre leader)

• Lucy V. Clark, PhD, Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine, Queen Mary University of London, London, UK

Health economists

• Martin Knapp

• Paul McCrone, PhD, Centre for the Economics of Mental Health Service and Population, King's College London, London, UK

Trial statisticians

• Rebecca Walwyn, MSc, Mental Health and Neuroscience Clinical Trials Unit, Institute of Psychiatry, King's College London, London, UK

• Anthony L. Johnson, PhD, Medical Research Council Biostatistics Unit, Institute of Public Health, University of Cambridge, UK and Medical Research Council Clinical Trials Unit, London, UK

• Laura Potts, MSc, Mental Health and Neuroscience Clinical Trials Unit, Institute of Psychiatry, King's College London, London, UK

• Kimberley A. Goldsmith, MSc, MPH, Mental Health and Neuroscience Clinical Trials Unit, Institute of Psychiatry, King's College London, London, UK (Served as main statistical analyst)

Trial Managers

• Julia C. DeCesare, MSc, Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine, Queen Mary University of London, London, UK

• Hannah L. Baber, MSc, Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine, Queen Mary University of London, London, UK

Data Manager/Senior Research Secretary

• Sandy Smith

Observers

• Chris Clark (for Action for ME)

• Sir Peter Spencer (for Action for ME)

• Alison Wearden (for the Fatigue Intervention by Nurses Evaluation trial aka FINE trial)

• Sir Mansel Aylward (Department for Work and Pensions, London, UK)

• Stephen Stansfeld (Queen Mary University of London, London, UK)

PACE Trial Management Group manuscripts

• 2006, PACE Final Protocol Version 5.0
• 2007, "Protocol for the PACE trial: A randomised controlled trial of adaptive pacing, cognitive behaviour therapy, and graded exercise as supplements to standardised specialist medical care versus standardised specialist medical care alone for patients with the chronic fatigue syndrome/myalgic encephalomyelitis or encephalopathy"
• 2011, "Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial"
• 2013, "Recovery from chronic fatigue syndrome after treatments given in the PACE trial"

PACE trial A controversial study which claimed that CBT and GET were effective in treating "CFS/ME", despite the fact that its own data did not support this conclusion. Its results and methodology were widely disputed by patients, scientists, and the peer-reviewed scientific literature.

Oxford University a prestigious university located in Oxford, England renowned for its teaching and research in health and medicine

PACE trial A controversial study which claimed that CBT and GET were effective in treating "CFS/ME", despite the fact that its own data did not support this conclusion. Its results and methodology were widely disputed by patients, scientists, and the peer-reviewed scientific literature.