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Multiple virus hypothesis
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
 | This article is a stub. |
Multiple virus hypothesis considers that ME/CFS is triggered and continued as a result of the body's response following exposure to multiple viruses, especially herpesviruses.[1]
In 2016, a study by Williams, et al, looked at lytic proteins produced during reactivation of the Epstein-Barr virus, in particular the deoxyuridine triphosphate nucleotidohydrolases (dUTPase), as key modulators of the host innate and adaptive immune responses. They considered "the possibility that two or more herpesviruses may act synergistically and that virus-encoded proteins, rather than the viruses themselves, may act as drivers of or contribute to the pathophysiological alterations observed in a subset of patients with ME/CFS."[1]
References[edit | edit source]
- ↑ Jump up to: 1.0 1.1 Williams, Marshall V.; Cox, Brandon; Ariza, Maria Eugenia (2017). "Herpesviruses dUTPases: A New Family of Pathogen-Associated Molecular Pattern (PAMP) Proteins with Implications for Human Disease". Pathogens. 6 (1): 2. doi:10.3390/pathogens6010002.
