Cobalamin

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Vitamin B12, also known as cobalamin, is a water-soluble vitamin, one of the B vitamins. Forms of cobalamin include hydroxo-cobalamin, cyano-cobalamin, methyl-cobalamin, and adenosyl-cobalamin.

Physiology[edit | edit source]

B12 is involved in cellular metabolism and formation of red blood cells (RBCs). It has an integral role in brain and nervous system function. Absorption of B12 from dietary sources requires an intrinsic factor (IF or GIF), i.e., a glycoprotein, synthesized in and secreted from parietal cells in the lining of the human stomach.

Immune system[edit | edit source]

Vitamin B12 deficiency may be associated with decreased natural killer cell activity.[1]

ME/CFS[edit | edit source]

Deficiency[edit | edit source]

See also
Vitamin B12 deficiency.

Notable studies[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ Tamura, J.; Kubota, K.; Murakami, H.; Sawamura, M.; Matsushima, T.; Tamura, T.; Saitoh, T.; Kurabayshi, H.; Naruse, T. (April 1, 1999), "Immunomodulation by vitamin B12: augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment", Clinical & Experimental Immunology, 116 (1): 28–32, doi:10.1046/j.1365-2249.1999.00870.x, ISSN 1365-2249, retrieved November 9, 2016
  2. ↑ Pall, Martin L. (2000). Cobalamin Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger. Journal of Chronic Fatigue Syndrome, Vol. 8, Iss. 2, pp. 39-44. doi: 10.1300/J092v08n02_04
  3. ↑ Regland, Björn; Forsmark, Sara; Halaouate, Lena; Matousek, Michael; Peilot, Birgitta; Zachrisson, Olof; Gottfries, Carl-Gerhard (2015), "Response to Vitamin B12 and Folic Acid in Myalgic Encephalomyelitis and Fibromyalgia.", PLoS ONE, 10 (4), doi:10.1371/journal.pone.0124648

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

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