From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

N6-methyladenosine or m6A is the N6 position of adenosine is vital for many different biological processes including transcription, translation and decay of mRNA.[1]

Function[edit | edit source]

Widespread mRNA methylation known as N6-adenosine methylation occurs at m6A, and it is believed to apply to all RNA viruses infections and some DNA viruses.[2]

In humans and other mammals m6A-related methyltransferases are mostly made up of a complex of methyltransferase-like protein 3 (METTL3) and methyltransferase-like protein 14 (METTL14).[1]

ME/CFS[edit | edit source]

Notable studies[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 1.2 McCaddon, Andrew; Björn, Regland (April 1, 2021). "COVID-19: A methyl-group assault?". Medical Hypotheses. 149: 110543. doi:10.1016/j.mehy.2021.110543. ISSN 0306-9877. PMC 7890339. PMID 33657459.
  2. Liu, Jianzhao; Yue, Yanan; Han, Dali; Wang, Xiao; Fu, Ye; Zhang, Liang; Jia, Guifang; Yu, Miao; Lu, Zhike (February 2014). "A METTL3–METTL14 complex mediates mammalian nuclear RNA N 6 -adenosine methylation". Nature Chemical Biology. 10 (2): 93–95. doi:10.1038/nchembio.1432. ISSN 1552-4469.