m6A
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
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N6-methyladenosine or m6A is the N6 position of adenosine is vital for many different biological processes including transcription, translation and decay of mRNA.[1]
Function[edit | edit source]
Widespread mRNA methylation known as N6-adenosine methylation occurs at m6A, and it is believed to apply to all RNA viruses infections and some DNA viruses.[2]
In humans and other mammals m6A-related methyltransferases are mostly made up of a complex of methyltransferase-like protein 3 (METTL3) and methyltransferase-like protein 14 (METTL14).[1]
ME/CFS[edit | edit source]
Notable studies[edit | edit source]
- 2021, COVID-19: A methyl-group assault?[1] (Full text)
See also[edit | edit source]
Learn more[edit | edit source]
References[edit | edit source]
- ↑ 1.0 1.1 1.2 McCaddon, Andrew; Björn, Regland (April 1, 2021). "COVID-19: A methyl-group assault?". Medical Hypotheses. 149: 110543. doi:10.1016/j.mehy.2021.110543. ISSN 0306-9877. PMC 7890339. PMID 33657459.
- ↑ Liu, Jianzhao; Yue, Yanan; Han, Dali; Wang, Xiao; Fu, Ye; Zhang, Liang; Jia, Guifang; Yu, Miao; Lu, Zhike (February 2014). "A METTL3–METTL14 complex mediates mammalian nuclear RNA N 6 -adenosine methylation". Nature Chemical Biology. 10 (2): 93–95. doi:10.1038/nchembio.1432. ISSN 1552-4469.
